Methylation-induced suppression of BEX1 activates AKT/ERK/STAT3 signaling pathways regulating cell cycle and apoptosis in glioma

Methylation-induced suppression of BEX1 activates AKT/ERK/STAT3 signaling pathways regulating cell cycle and apoptosis in glioma

Abstract Gliomas are highly aggressive brain tumors with complex molecular characteristics. The role of BEX1 methylation in gliomas is not well understood, despite its potential implications for tumor biology and therapy. Investigating this relationship could uncover critical mechanisms underlying g...

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Bibliographic Details
Main Authors: Li-Zhi Xiao, Shi Feng, Zhen He, Rui Mao, Kai Qian, Zhi-Ying Zhou, Huabao Cai, Mengyu Zhao, Cunzhi Wang, Tianhang Yu, Zi-Yu Zhao, Jie Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Giloma
BEX1
Methylation
PI3K/ERK/STAT3
Clinical translation
Online Access:https://doi.org/10.1038/s41598-025-14123-8
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