Dexamethasone conjugation to an Avidin-Nucleic-Acid-NanoASsembly eliminates the steroid plasma absorption, enhancing selective lung tropism in a murine model of pulmonary fibrosis

Dexamethasone conjugation to an Avidin-Nucleic-Acid-NanoASsembly eliminates the steroid plasma absorption, enhancing selective lung tropism in a murine model of pulmonary fibrosis

Despite their anti-inflammatory activity, corticosteroids are limited in clinic due to poor selectivity and their side effects. The ability to cross biological barriers makes them powerful yet unspecific, leading to toxicity and a low therapeutic index that limits their chronic use in autoimmune, in...

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Bibliographic Details
Main Authors: Annalisa Morelli, Elisa Schiavon, Martina Bruna Violatto, Giulia Yuri Moscatiello, Anita Salmaso, Alice Passoni, Alessia Lanno, Simone Bernardotto, Martina Stocco, Andrea Mattarei, Renzo Bagnati, Federica Meloni, Paolo Bigini, Margherita Morpurgo
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
Lung fibrosis
nanoparticles
intranasal administration
inflammation
corticosteroids
drug delivery
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2531063
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