The burden of parasitic zoonoses in Nepal: a systematic review.
<h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disabilit...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002634&type=printable |
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| author | Brecht Devleesschauwer Anita Ale Paul Torgerson Nicolas Praet Charline Maertens de Noordhout Basu Dev Pandey Sher Bahadur Pun Rob Lake Jozef Vercruysse Durga Datt Joshi Arie H Havelaar Luc Duchateau Pierre Dorny Niko Speybroeck |
| author_facet | Brecht Devleesschauwer Anita Ale Paul Torgerson Nicolas Praet Charline Maertens de Noordhout Basu Dev Pandey Sher Bahadur Pun Rob Lake Jozef Vercruysse Durga Datt Joshi Arie H Havelaar Luc Duchateau Pierre Dorny Niko Speybroeck |
| author_sort | Brecht Devleesschauwer |
| collection | DOAJ |
| description | <h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding.<h4>Methodology</h4>We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs.<h4>Principal findings</h4>Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450-27,694] and 9255 DALYs [95% CrI: 6135-13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105-458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur.<h4>Conclusions/significance</h4>In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases. |
| format | Article |
| id | doaj-art-dc8574ac984b4f2ab6b6d14ef7eba30a |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-dc8574ac984b4f2ab6b6d14ef7eba30a2025-08-20T03:09:23ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-01-0181e263410.1371/journal.pntd.0002634The burden of parasitic zoonoses in Nepal: a systematic review.Brecht DevleesschauwerAnita AlePaul TorgersonNicolas PraetCharline Maertens de NoordhoutBasu Dev PandeySher Bahadur PunRob LakeJozef VercruysseDurga Datt JoshiArie H HavelaarLuc DuchateauPierre DornyNiko Speybroeck<h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding.<h4>Methodology</h4>We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs.<h4>Principal findings</h4>Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450-27,694] and 9255 DALYs [95% CrI: 6135-13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105-458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur.<h4>Conclusions/significance</h4>In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002634&type=printable |
| spellingShingle | Brecht Devleesschauwer Anita Ale Paul Torgerson Nicolas Praet Charline Maertens de Noordhout Basu Dev Pandey Sher Bahadur Pun Rob Lake Jozef Vercruysse Durga Datt Joshi Arie H Havelaar Luc Duchateau Pierre Dorny Niko Speybroeck The burden of parasitic zoonoses in Nepal: a systematic review. PLoS Neglected Tropical Diseases |
| title | The burden of parasitic zoonoses in Nepal: a systematic review. |
| title_full | The burden of parasitic zoonoses in Nepal: a systematic review. |
| title_fullStr | The burden of parasitic zoonoses in Nepal: a systematic review. |
| title_full_unstemmed | The burden of parasitic zoonoses in Nepal: a systematic review. |
| title_short | The burden of parasitic zoonoses in Nepal: a systematic review. |
| title_sort | burden of parasitic zoonoses in nepal a systematic review |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002634&type=printable |
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