Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults
Abstract Background Sleep is a crucial lifestyle factor with impacts on mental and cognitive health. The associations between objectively measured sleep and risk of incident dementia are not yet fully understood. To evaluate the associations of device-measured sleep duration and regularity with inci...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-21649-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861598551277568 |
|---|---|
| author | Wenxin Bian Raaj K. Biswas Matthew N. Ahmadi Yu Sun Bin Svetlana Postnova Andrew J. K. Phillips Nicholas A. Koemel Jean-Philippe Chaput Shantha M. W. Rajaratnam Peter A. Cistulli Emmanuel Stamatakis |
| author_facet | Wenxin Bian Raaj K. Biswas Matthew N. Ahmadi Yu Sun Bin Svetlana Postnova Andrew J. K. Phillips Nicholas A. Koemel Jean-Philippe Chaput Shantha M. W. Rajaratnam Peter A. Cistulli Emmanuel Stamatakis |
| author_sort | Wenxin Bian |
| collection | DOAJ |
| description | Abstract Background Sleep is a crucial lifestyle factor with impacts on mental and cognitive health. The associations between objectively measured sleep and risk of incident dementia are not yet fully understood. To evaluate the associations of device-measured sleep duration and regularity with incident dementia and explore whether sleep regularity moderates the association of sleep duration with dementia. Methods Population-based prospective cohort study of 82,391 adults aged 43 to 79 years from the UK Biobank accelerometry subsample, collected between 2013 and 2015, followed up to 2022. Device-based sleep duration (h/day) and sleep regularity index (SRI), a metric ranging from 0-100 that quantifies a person’s sleep regularity (with a greater value indicating higher consistency), were calculated from wrist-worn accelerometry data recorded over the course of one week. Incident all-cause dementia cases were obtained from national hospital admission, primary care and mortality data followed up to 30 November 2022. We used Cox proportional hazard models to estimate the hazard ratios (HRs) for incident dementia after adjustment for common demographic and clinical covariates. Results Over a mean follow-up of 7.9 years, 694 incident dementia cases occurred. We observed a U-shaped association between sleep duration and incident dementia, with only short sleep (< 7 h) being significantly associated with a higher risk of dementia. The median sleep duration for short sleepers (< 7 h) of 6.5 h, compared to the reference point of 7.9 h was associated with HR of 1.19 (95%CI 1.01,1.40) for incident dementia. Sleep regularity was negatively associated with dementia risk in a near-linear fashion (linear p = 0.01, non-linear p = 0.57). When we dichotomized sleep regularity, those in the higher sleep regularity group (SRI ≥ 70) had an HR of 0.74 (95%CI 0.63, 0.87) compared to those with lower sleep regularity (SRI < 70). The beneficial associations between sleep regularity and incident dementia were present only among participants with short (< 7 h) and long (≥ 8 h) sleep duration. Conclusions Assuming that the associations we observed are causal, maintaining a regular sleep pattern may help offset the deleterious association of inadequate sleep duration with dementia. Interventions aimed at improving sleep regularity may be a viable option for people not able to achieve the recommended hours of sleep. |
| format | Article |
| id | doaj-art-dc854e9ae5124150a741c554298c0705 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-dc854e9ae5124150a741c554298c07052025-02-09T12:57:52ZengBMCBMC Public Health1471-24582025-02-0125111010.1186/s12889-025-21649-zDose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adultsWenxin Bian0Raaj K. Biswas1Matthew N. Ahmadi2Yu Sun Bin3Svetlana Postnova4Andrew J. K. Phillips5Nicholas A. Koemel6Jean-Philippe Chaput7Shantha M. W. Rajaratnam8Peter A. Cistulli9Emmanuel Stamatakis10Mackenzie Wearables Research Hub, Charles Perkins Centre, University of SydneyMackenzie Wearables Research Hub, Charles Perkins Centre, University of SydneyMackenzie Wearables Research Hub, Charles Perkins Centre, University of SydneyNorthern Clinical School, Faculty of Medicine and Health, University of SydneySleep Research Group, Charles Perkins Centre, University of SydneySchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash UniversityMackenzie Wearables Research Hub, Charles Perkins Centre, University of SydneyHealthy Active Living and Obesity Research Group, Children‘s Hospital of Eastern Ontario Research InstituteSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash UniversityNorthern Clinical School, Faculty of Medicine and Health, University of SydneyMackenzie Wearables Research Hub, Charles Perkins Centre, University of SydneyAbstract Background Sleep is a crucial lifestyle factor with impacts on mental and cognitive health. The associations between objectively measured sleep and risk of incident dementia are not yet fully understood. To evaluate the associations of device-measured sleep duration and regularity with incident dementia and explore whether sleep regularity moderates the association of sleep duration with dementia. Methods Population-based prospective cohort study of 82,391 adults aged 43 to 79 years from the UK Biobank accelerometry subsample, collected between 2013 and 2015, followed up to 2022. Device-based sleep duration (h/day) and sleep regularity index (SRI), a metric ranging from 0-100 that quantifies a person’s sleep regularity (with a greater value indicating higher consistency), were calculated from wrist-worn accelerometry data recorded over the course of one week. Incident all-cause dementia cases were obtained from national hospital admission, primary care and mortality data followed up to 30 November 2022. We used Cox proportional hazard models to estimate the hazard ratios (HRs) for incident dementia after adjustment for common demographic and clinical covariates. Results Over a mean follow-up of 7.9 years, 694 incident dementia cases occurred. We observed a U-shaped association between sleep duration and incident dementia, with only short sleep (< 7 h) being significantly associated with a higher risk of dementia. The median sleep duration for short sleepers (< 7 h) of 6.5 h, compared to the reference point of 7.9 h was associated with HR of 1.19 (95%CI 1.01,1.40) for incident dementia. Sleep regularity was negatively associated with dementia risk in a near-linear fashion (linear p = 0.01, non-linear p = 0.57). When we dichotomized sleep regularity, those in the higher sleep regularity group (SRI ≥ 70) had an HR of 0.74 (95%CI 0.63, 0.87) compared to those with lower sleep regularity (SRI < 70). The beneficial associations between sleep regularity and incident dementia were present only among participants with short (< 7 h) and long (≥ 8 h) sleep duration. Conclusions Assuming that the associations we observed are causal, maintaining a regular sleep pattern may help offset the deleterious association of inadequate sleep duration with dementia. Interventions aimed at improving sleep regularity may be a viable option for people not able to achieve the recommended hours of sleep.https://doi.org/10.1186/s12889-025-21649-zActigraphySleep patternSleep regularitySleep durationDementiaPublic health |
| spellingShingle | Wenxin Bian Raaj K. Biswas Matthew N. Ahmadi Yu Sun Bin Svetlana Postnova Andrew J. K. Phillips Nicholas A. Koemel Jean-Philippe Chaput Shantha M. W. Rajaratnam Peter A. Cistulli Emmanuel Stamatakis Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults BMC Public Health Actigraphy Sleep pattern Sleep regularity Sleep duration Dementia Public health |
| title | Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults |
| title_full | Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults |
| title_fullStr | Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults |
| title_full_unstemmed | Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults |
| title_short | Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults |
| title_sort | dose response associations of device measured sleep regularity and duration with incident dementia in 82391 uk adults |
| topic | Actigraphy Sleep pattern Sleep regularity Sleep duration Dementia Public health |
| url | https://doi.org/10.1186/s12889-025-21649-z |
| work_keys_str_mv | AT wenxinbian doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT raajkbiswas doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT matthewnahmadi doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT yusunbin doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT svetlanapostnova doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT andrewjkphillips doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT nicholasakoemel doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT jeanphilippechaput doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT shanthamwrajaratnam doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT peteracistulli doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults AT emmanuelstamatakis doseresponseassociationsofdevicemeasuredsleepregularityanddurationwithincidentdementiain82391ukadults |