Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations

Common metabolic and endocrine alterations exist across a wide range of muscular dystrophies. Skeletal muscle plays an important role in glucose metabolism and is a major participant in different signaling pathways. Therefore, its damage may lead to different metabolic disruptions. Two of the most i...

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Main Authors: Oriana del Rocío Cruz Guzmán, Ana Laura Chávez García, Maricela Rodríguez-Cruz
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2012/485376
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author Oriana del Rocío Cruz Guzmán
Ana Laura Chávez García
Maricela Rodríguez-Cruz
author_facet Oriana del Rocío Cruz Guzmán
Ana Laura Chávez García
Maricela Rodríguez-Cruz
author_sort Oriana del Rocío Cruz Guzmán
collection DOAJ
description Common metabolic and endocrine alterations exist across a wide range of muscular dystrophies. Skeletal muscle plays an important role in glucose metabolism and is a major participant in different signaling pathways. Therefore, its damage may lead to different metabolic disruptions. Two of the most important metabolic alterations in muscular dystrophies may be insulin resistance and obesity. However, only insulin resistance has been demonstrated in myotonic dystrophy. In addition, endocrine disturbances such as hypogonadism, low levels of testosterone, and growth hormone have been reported. This eventually will result in consequences such as growth failure and delayed puberty in the case of childhood dystrophies. Other consequences may be reduced male fertility, reduced spermatogenesis, and oligospermia, both in childhood as well as in adult muscular dystrophies. These facts all suggest that there is a need for better comprehension of metabolic and endocrine implications for muscular dystrophies with the purpose of developing improved clinical treatments and/or improvements in the quality of life of patients with dystrophy. Therefore, the aim of this paper is to describe the current knowledge about of metabolic and endocrine alterations in diverse types of dystrophinopathies, which will be divided into two groups: childhood and adult dystrophies which have different age of onset.
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spelling doaj-art-dc84d0c6eac94c65a7752f0f89c3a2ce2025-02-03T01:30:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/485376485376Muscular Dystrophies at Different Ages: Metabolic and Endocrine AlterationsOriana del Rocío Cruz Guzmán0Ana Laura Chávez García1Maricela Rodríguez-Cruz2Laboratorio de Biología Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, 06703 Ciudad México, DF, MexicoLaboratorio de Biología Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, 06703 Ciudad México, DF, MexicoLaboratorio de Biología Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, 06703 Ciudad México, DF, MexicoCommon metabolic and endocrine alterations exist across a wide range of muscular dystrophies. Skeletal muscle plays an important role in glucose metabolism and is a major participant in different signaling pathways. Therefore, its damage may lead to different metabolic disruptions. Two of the most important metabolic alterations in muscular dystrophies may be insulin resistance and obesity. However, only insulin resistance has been demonstrated in myotonic dystrophy. In addition, endocrine disturbances such as hypogonadism, low levels of testosterone, and growth hormone have been reported. This eventually will result in consequences such as growth failure and delayed puberty in the case of childhood dystrophies. Other consequences may be reduced male fertility, reduced spermatogenesis, and oligospermia, both in childhood as well as in adult muscular dystrophies. These facts all suggest that there is a need for better comprehension of metabolic and endocrine implications for muscular dystrophies with the purpose of developing improved clinical treatments and/or improvements in the quality of life of patients with dystrophy. Therefore, the aim of this paper is to describe the current knowledge about of metabolic and endocrine alterations in diverse types of dystrophinopathies, which will be divided into two groups: childhood and adult dystrophies which have different age of onset.http://dx.doi.org/10.1155/2012/485376
spellingShingle Oriana del Rocío Cruz Guzmán
Ana Laura Chávez García
Maricela Rodríguez-Cruz
Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
International Journal of Endocrinology
title Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
title_full Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
title_fullStr Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
title_full_unstemmed Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
title_short Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations
title_sort muscular dystrophies at different ages metabolic and endocrine alterations
url http://dx.doi.org/10.1155/2012/485376
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AT maricelarodriguezcruz musculardystrophiesatdifferentagesmetabolicandendocrinealterations