Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D

Background: It has recently been observed that the phenotype of patients with type 1 diabetes (T1D) is changing. Objective: To identify parameters that allow the recognition of metabolic syndrome (MS) and insulin resistance (IR) in adult patients with T1D. Methods: We formed four groups based on the...

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Main Authors: Germán A. Nolasco-Rosales, Juan D. Cruz-Castillo, Ester Rodríguez-Sánchez, Karla I. Jiménez-López, José J. Martínez-Magaña, Guillermo E. Villar-Juárez, Yazmín Hernández-Díaz, Carlos A. Tovilla-Zárate, Crystell G. Guzmán-Priego, Alejandro Marín-Medina, Isela E. Juárez-Rojo
Format: Article
Language:English
Published: Permanyer 2025-04-01
Series:Revista Mexicana de Endocrinología, Metabolismo y Nutrición
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Online Access:http://www.revistadeendocrinologia.com/frame_eng.php?id=366
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author Germán A. Nolasco-Rosales
Juan D. Cruz-Castillo
Ester Rodríguez-Sánchez
Karla I. Jiménez-López
José J. Martínez-Magaña
Guillermo E. Villar-Juárez
Yazmín Hernández-Díaz
Carlos A. Tovilla-Zárate
Crystell G. Guzmán-Priego
Alejandro Marín-Medina
Isela E. Juárez-Rojo
author_facet Germán A. Nolasco-Rosales
Juan D. Cruz-Castillo
Ester Rodríguez-Sánchez
Karla I. Jiménez-López
José J. Martínez-Magaña
Guillermo E. Villar-Juárez
Yazmín Hernández-Díaz
Carlos A. Tovilla-Zárate
Crystell G. Guzmán-Priego
Alejandro Marín-Medina
Isela E. Juárez-Rojo
author_sort Germán A. Nolasco-Rosales
collection DOAJ
description Background: It has recently been observed that the phenotype of patients with type 1 diabetes (T1D) is changing. Objective: To identify parameters that allow the recognition of metabolic syndrome (MS) and insulin resistance (IR) in adult patients with T1D. Methods: We formed four groups based on the presence of MS and IR: MS + IR + (n = 5), MS + IR – (n = 3), MS – IR + (n = 5), and MS – IR – (n = 6). The receiver operating curves (ROC) evaluated the sensitivity and specificity for MS and peripheral IR detection. Results: Eight patients (42.10%) had MS, and 10 (52.6%) had IR. We observed differences between the groups in the ratio of triglycerides to HDL cholesterol, levels of glycosylated hemoglobin, and HDL-c. A triglycerides/HDL ratio > 2.82, and glycosylated hemoglobin level > 8.7% correlated best with the presence of MS and IR, respectively. Conclusion: The triglycerides/HDL ratio could predict MS in adult patients with T1D. Furthermore, the eGDR could detect IR without clinical features of MS in patients with T1D.
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issn 2462-4144
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series Revista Mexicana de Endocrinología, Metabolismo y Nutrición
spelling doaj-art-dc802397a12c49c1933b461a310a1ea02025-08-20T03:28:38ZengPermanyerRevista Mexicana de Endocrinología, Metabolismo y Nutrición2462-41442025-04-0112210.24875/RME.24000026Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1DGermán A. Nolasco-Rosales0Juan D. Cruz-Castillo1Ester Rodríguez-Sánchez2Karla I. Jiménez-López3José J. Martínez-Magaña4Guillermo E. Villar-Juárez5Yazmín Hernández-Díaz6Carlos A. Tovilla-Zárate7Crystell G. Guzmán-Priego8Alejandro Marín-Medina9Isela E. Juárez-Rojo101Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., MexicoAcademic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., MexicoDiabetes Clinic,, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa, Tab., MexicoAcademic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., MexicoDepartment of Psychiatry, Yale University School of Medicine, New Haven, USAMedicine School, Universidad Anáhuac Querétaro, Qro., MexicoMultidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tab., MexicoComalcalco Multidisciplinary Academic Division, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tab., MexicoAcademic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., MexicoUniversity Center for Health Sciences, Universidad de Guadalajara, Guadalajara, Jal., MexicoAcademic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., MexicoBackground: It has recently been observed that the phenotype of patients with type 1 diabetes (T1D) is changing. Objective: To identify parameters that allow the recognition of metabolic syndrome (MS) and insulin resistance (IR) in adult patients with T1D. Methods: We formed four groups based on the presence of MS and IR: MS + IR + (n = 5), MS + IR – (n = 3), MS – IR + (n = 5), and MS – IR – (n = 6). The receiver operating curves (ROC) evaluated the sensitivity and specificity for MS and peripheral IR detection. Results: Eight patients (42.10%) had MS, and 10 (52.6%) had IR. We observed differences between the groups in the ratio of triglycerides to HDL cholesterol, levels of glycosylated hemoglobin, and HDL-c. A triglycerides/HDL ratio > 2.82, and glycosylated hemoglobin level > 8.7% correlated best with the presence of MS and IR, respectively. Conclusion: The triglycerides/HDL ratio could predict MS in adult patients with T1D. Furthermore, the eGDR could detect IR without clinical features of MS in patients with T1D. http://www.revistadeendocrinologia.com/frame_eng.php?id=366Type 1 diabetes. Metabolic syndrome. Insulin resistance. High-density lipoprotein cholesterol. Triglycerides. Glycated hemoglobin A.
spellingShingle Germán A. Nolasco-Rosales
Juan D. Cruz-Castillo
Ester Rodríguez-Sánchez
Karla I. Jiménez-López
José J. Martínez-Magaña
Guillermo E. Villar-Juárez
Yazmín Hernández-Díaz
Carlos A. Tovilla-Zárate
Crystell G. Guzmán-Priego
Alejandro Marín-Medina
Isela E. Juárez-Rojo
Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
Revista Mexicana de Endocrinología, Metabolismo y Nutrición
Type 1 diabetes. Metabolic syndrome. Insulin resistance. High-density lipoprotein cholesterol. Triglycerides. Glycated hemoglobin A.
title Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
title_full Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
title_fullStr Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
title_full_unstemmed Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
title_short Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
title_sort triglycerides hdl ratio and hba1c to discriminate metabolic syndrome and insulin resistance in adults with t1d
topic Type 1 diabetes. Metabolic syndrome. Insulin resistance. High-density lipoprotein cholesterol. Triglycerides. Glycated hemoglobin A.
url http://www.revistadeendocrinologia.com/frame_eng.php?id=366
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