Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications
Cervical cancer (CC) is the primary cause of cancer-related mortality among women in developing countries and is the most prevalent disease linked to human papillomavirus (HPV). Over 70 % of CC cases result from persistent infections with high-risk HPV types. The virus typically targets the mucocuta...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325000944 |
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| author | Mina Alimohammadi Abbas Ali Imani Fooladi Alireza Mafi Seyedeh Mana Alavioun William C. Cho Russel J Reiter Fateme Zare Khormizi Tooba Yousefi Najma Farahani Seyedeh Mahdieh Khoshnazar Kiavash Hushmandi |
| author_facet | Mina Alimohammadi Abbas Ali Imani Fooladi Alireza Mafi Seyedeh Mana Alavioun William C. Cho Russel J Reiter Fateme Zare Khormizi Tooba Yousefi Najma Farahani Seyedeh Mahdieh Khoshnazar Kiavash Hushmandi |
| author_sort | Mina Alimohammadi |
| collection | DOAJ |
| description | Cervical cancer (CC) is the primary cause of cancer-related mortality among women in developing countries and is the most prevalent disease linked to human papillomavirus (HPV). Over 70 % of CC cases result from persistent infections with high-risk HPV types. The virus typically targets the mucocutaneous epithelium, generating viral particles in mature epithelial cells, which leads to disruptions in normal cell-cycle regulation and promotes uncontrolled cellular proliferation. This unchecked cell division results in the accumulation of genetic damage, contributing to the pathogenesis of CC. While HPV infection is a key etiological factor, the disease's progression also necessitates the involvement of genetic and epigenetic influences. One of the epigenetic regulators, long noncoding RNAs (lncRNAs), are characterized by transcripts exceeding 200 nucleotides. These molecules play crucial roles in various cellular processes, including transcription regulation, RNA metaboli35 per 100,000sm, and apoptosis. Investigating the specific roles of lncRNAs in modulating gene expression related to the oncogenic mechanisms of CC, particularly in the context of high-risk HPV infections, may provide valuable insights for diagnostic and therapeutic advancements. Herein, we first review key molecular mechanisms by which lncRNAs interfere with CC-related HPV development. Then, diagnostic, prognostic, and therapeutic potentials of these lncRNA molecules will be highlighted in depth. The focus of this article is on the role of lncRNAs associated with HPV-related CC, emphasizing the investigation of signaling pathways and their underlying molecular mechanisms. Furthermore, we explore the therapeutic potential and diagnostic relevance of the most significant lncRNAs in the context of CC, thereby highlighting their importance in advancing treatment strategies and improving patient outcomes. |
| format | Article |
| id | doaj-art-dc7cd97d0fff48c1b5476d236b357659 |
| institution | OA Journals |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-dc7cd97d0fff48c1b5476d236b3576592025-08-20T02:15:51ZengElsevierTranslational Oncology1936-52332025-05-015510236310.1016/j.tranon.2025.102363Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applicationsMina Alimohammadi0Abbas Ali Imani Fooladi1Alireza Mafi2Seyedeh Mana Alavioun3William C. Cho4Russel J Reiter5Fateme Zare Khormizi6Tooba Yousefi7Najma Farahani8Seyedeh Mahdieh Khoshnazar9Kiavash Hushmandi10Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranApplied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, IranNutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Basic sciences, Faculty of Veterinary Medicine, Urmia university, Urmia, IranDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong KongDepartment of Cell Systems and Anatomy, UT Health San Antonio, Long School of Medicine, San Antonio, TX, USADepartment of Biology, Yazd University, Yazd, IranDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding authors.Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran; Corresponding authors.Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; Corresponding authors.Cervical cancer (CC) is the primary cause of cancer-related mortality among women in developing countries and is the most prevalent disease linked to human papillomavirus (HPV). Over 70 % of CC cases result from persistent infections with high-risk HPV types. The virus typically targets the mucocutaneous epithelium, generating viral particles in mature epithelial cells, which leads to disruptions in normal cell-cycle regulation and promotes uncontrolled cellular proliferation. This unchecked cell division results in the accumulation of genetic damage, contributing to the pathogenesis of CC. While HPV infection is a key etiological factor, the disease's progression also necessitates the involvement of genetic and epigenetic influences. One of the epigenetic regulators, long noncoding RNAs (lncRNAs), are characterized by transcripts exceeding 200 nucleotides. These molecules play crucial roles in various cellular processes, including transcription regulation, RNA metaboli35 per 100,000sm, and apoptosis. Investigating the specific roles of lncRNAs in modulating gene expression related to the oncogenic mechanisms of CC, particularly in the context of high-risk HPV infections, may provide valuable insights for diagnostic and therapeutic advancements. Herein, we first review key molecular mechanisms by which lncRNAs interfere with CC-related HPV development. Then, diagnostic, prognostic, and therapeutic potentials of these lncRNA molecules will be highlighted in depth. The focus of this article is on the role of lncRNAs associated with HPV-related CC, emphasizing the investigation of signaling pathways and their underlying molecular mechanisms. Furthermore, we explore the therapeutic potential and diagnostic relevance of the most significant lncRNAs in the context of CC, thereby highlighting their importance in advancing treatment strategies and improving patient outcomes.http://www.sciencedirect.com/science/article/pii/S1936523325000944Uterine cervical neoplasmCCHuman papilloma virus (HPV)Long noncoding RNA (lnRNA)Signal transductionDiagnosis |
| spellingShingle | Mina Alimohammadi Abbas Ali Imani Fooladi Alireza Mafi Seyedeh Mana Alavioun William C. Cho Russel J Reiter Fateme Zare Khormizi Tooba Yousefi Najma Farahani Seyedeh Mahdieh Khoshnazar Kiavash Hushmandi Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications Translational Oncology Uterine cervical neoplasm CC Human papilloma virus (HPV) Long noncoding RNA (lnRNA) Signal transduction Diagnosis |
| title | Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications |
| title_full | Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications |
| title_fullStr | Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications |
| title_full_unstemmed | Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications |
| title_short | Long noncoding RNAs and HPV-related cervical cancer: Uncovering molecular mechanisms and clinical applications |
| title_sort | long noncoding rnas and hpv related cervical cancer uncovering molecular mechanisms and clinical applications |
| topic | Uterine cervical neoplasm CC Human papilloma virus (HPV) Long noncoding RNA (lnRNA) Signal transduction Diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325000944 |
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