Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration
Cutaneous wound healing is a complex multiple phase process, which overlaps each other, where several growth factors, cytokines, chemokines, and various cells interact in a well-orchestrated manner. However, an imbalance in any of these phases and factors may lead to disruption in harmony of normal...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5217967 |
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| _version_ | 1850165894372655104 |
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| author | Suman Kanji Hiranmoy Das |
| author_facet | Suman Kanji Hiranmoy Das |
| author_sort | Suman Kanji |
| collection | DOAJ |
| description | Cutaneous wound healing is a complex multiple phase process, which overlaps each other, where several growth factors, cytokines, chemokines, and various cells interact in a well-orchestrated manner. However, an imbalance in any of these phases and factors may lead to disruption in harmony of normal wound healing process, resulting in transformation towards chronic nonhealing wounds and abnormal scar formation. Although various therapeutic interventions are available to treat chronic wounds, current wound-care has met with limited success. Progenitor stem cells possess potential therapeutic ability to overcome limitations of the present treatments as it offers accelerated wound repair with tissue regeneration. A substantial number of stem cell therapies for cutaneous wounds are currently under development as a result of encouraging preliminary findings in both preclinical and clinical studies. However, the mechanisms by which these stem cells contribute to the healing process have yet to be elucidated. In this review, we emphasize on the major treatment modalities currently available for the treatment of the wound, role of various interstitial stem cells and exogenous adult stem cells in cutaneous wound healing, and possible mechanisms involved in the healing process. |
| format | Article |
| id | doaj-art-dc7155fd1d4044f6ae7b0a2e2d2620fd |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dc7155fd1d4044f6ae7b0a2e2d2620fd2025-08-20T02:21:37ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/52179675217967Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and RegenerationSuman Kanji0Hiranmoy Das1Cardiovascular Stem Cell Research Laboratory, Wexner Medical Center, The Ohio State University, Columbus, OH, USAVascular Biology and Stem Cell Research Laboratory, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USACutaneous wound healing is a complex multiple phase process, which overlaps each other, where several growth factors, cytokines, chemokines, and various cells interact in a well-orchestrated manner. However, an imbalance in any of these phases and factors may lead to disruption in harmony of normal wound healing process, resulting in transformation towards chronic nonhealing wounds and abnormal scar formation. Although various therapeutic interventions are available to treat chronic wounds, current wound-care has met with limited success. Progenitor stem cells possess potential therapeutic ability to overcome limitations of the present treatments as it offers accelerated wound repair with tissue regeneration. A substantial number of stem cell therapies for cutaneous wounds are currently under development as a result of encouraging preliminary findings in both preclinical and clinical studies. However, the mechanisms by which these stem cells contribute to the healing process have yet to be elucidated. In this review, we emphasize on the major treatment modalities currently available for the treatment of the wound, role of various interstitial stem cells and exogenous adult stem cells in cutaneous wound healing, and possible mechanisms involved in the healing process.http://dx.doi.org/10.1155/2017/5217967 |
| spellingShingle | Suman Kanji Hiranmoy Das Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration Mediators of Inflammation |
| title | Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration |
| title_full | Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration |
| title_fullStr | Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration |
| title_full_unstemmed | Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration |
| title_short | Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration |
| title_sort | advances of stem cell therapeutics in cutaneous wound healing and regeneration |
| url | http://dx.doi.org/10.1155/2017/5217967 |
| work_keys_str_mv | AT sumankanji advancesofstemcelltherapeuticsincutaneouswoundhealingandregeneration AT hiranmoydas advancesofstemcelltherapeuticsincutaneouswoundhealingandregeneration |