Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice
This study involved the evaluation of Alcoholic extract of Nerium Oleander L. plant that have a promising anticancer cell. This extract was compared to the well known anticancer drug Cis – Platinum by utilizing an in vivo system in female Albino mice. The first direction was cytogenetically using th...
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University of Baghdad, College of Science for Women
2011-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2811 |
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| description | This study involved the evaluation of Alcoholic extract of Nerium Oleander L. plant that have a promising anticancer cell. This extract was compared to the well known anticancer drug Cis – Platinum by utilizing an in vivo system in female Albino mice. The first direction was cytogenetically using the mitotic Index of bone marrow cells as a parameter for the cytotoxic effect of this extract. The second direction was enzymatical using a widely distributed enzyme GOT in the different organs of mice: Liver , kidney , spleen and lung . Animals were treated with three doses of Cis-platin , 50 , 200 and 350 Mg/mouse for three days . The same doses were used for the other extract . This study showed that the extract have a promising anticancer cell as could be seen from these effect on mitotic Index (MI) of mice bone marrow , (MI) decreased in animals treated with different doses of extract , mitotic index was reduced to 78% on day three in animals treated with 350 ?g/mouse . These effects were similar to the effect of Cis-platin at the same doses. Comparing the effect of this extract on GOT enzyme showed that Cis-platin was more effective on activating the spleen GOT enzyme of about 95% than the extract while the extract is more effective in Lung , The extract activated GOT enzyme activity in the all organs. |
| format | Article |
| id | doaj-art-dc6b810b4e1d445494718df5a181acd1 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2011-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-dc6b810b4e1d445494718df5a181acd12025-08-20T03:58:50ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862011-06-018210.21123/bsj.8.2.359-365Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino miceBaghdad Science JournalThis study involved the evaluation of Alcoholic extract of Nerium Oleander L. plant that have a promising anticancer cell. This extract was compared to the well known anticancer drug Cis – Platinum by utilizing an in vivo system in female Albino mice. The first direction was cytogenetically using the mitotic Index of bone marrow cells as a parameter for the cytotoxic effect of this extract. The second direction was enzymatical using a widely distributed enzyme GOT in the different organs of mice: Liver , kidney , spleen and lung . Animals were treated with three doses of Cis-platin , 50 , 200 and 350 Mg/mouse for three days . The same doses were used for the other extract . This study showed that the extract have a promising anticancer cell as could be seen from these effect on mitotic Index (MI) of mice bone marrow , (MI) decreased in animals treated with different doses of extract , mitotic index was reduced to 78% on day three in animals treated with 350 ?g/mouse . These effects were similar to the effect of Cis-platin at the same doses. Comparing the effect of this extract on GOT enzyme showed that Cis-platin was more effective on activating the spleen GOT enzyme of about 95% than the extract while the extract is more effective in Lung , The extract activated GOT enzyme activity in the all organs.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2811: Nerium oleander , Cisplatin , GOT , Cytotoxicity |
| spellingShingle | Baghdad Science Journal Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice مجلة بغداد للعلوم : Nerium oleander , Cisplatin , GOT , Cytotoxicity |
| title | Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice |
| title_full | Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice |
| title_fullStr | Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice |
| title_full_unstemmed | Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice |
| title_short | Study of cytotoxic Effects Alcoholic Nerium Oleander L. Extract on female Albino mice |
| title_sort | study of cytotoxic effects alcoholic nerium oleander l extract on female albino mice |
| topic | : Nerium oleander , Cisplatin , GOT , Cytotoxicity |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2811 |
| work_keys_str_mv | AT baghdadsciencejournal studyofcytotoxiceffectsalcoholicneriumoleanderlextractonfemalealbinomice |