Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study
Background: This study compared the drug release kinetics of Terminalia arjuna mediated selenium nanoparticles (SeNPs) gel and zinc oxide nanoparticles (ZnONPs) gel for their potential in local drug delivery for chronic periodontitis. Material and method: The drug release was evaluated in-vitro by c...
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Elsevier
2025-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824001878 |
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| author | R. Vijayalakshmi N. Ambalavanan S. Rajeshkumar Jaideep Mahendra Uma Sudhakar Devi Parameswari |
| author_facet | R. Vijayalakshmi N. Ambalavanan S. Rajeshkumar Jaideep Mahendra Uma Sudhakar Devi Parameswari |
| author_sort | R. Vijayalakshmi |
| collection | DOAJ |
| description | Background: This study compared the drug release kinetics of Terminalia arjuna mediated selenium nanoparticles (SeNPs) gel and zinc oxide nanoparticles (ZnONPs) gel for their potential in local drug delivery for chronic periodontitis. Material and method: The drug release was evaluated in-vitro by conducting tests on different formulations, including 1 %, 2 %, 3 %, 4 %, and 5 % Terminalia arjuna mediated SeNPs gel and ZnONPs gel. Each sample, approximately 0.1 mg, was mixed with 10 mL of phosphate buffer saline (PBS) at various pH levels and maintained at 37 °C. The suspension was then placed in an incubated shaker at 120 rpm for 1 h. Five-milliliter samples were withdrawn from the dissolution medium at 30-min intervals and replaced with fresh PBS buffer to maintain a constant volume. The released drug amount was measured using a UV spectrophotometer (Systronics, India) at 290 nm. Result: The investigation revealed that SeNPs gel exhibited higher drug release percentages compared to ZnONPs gel across various concentrations and time points. The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. The near-complete release of the drug at 500 min highlights the potential for prolonged therapeutic efficacy, reducing the need for frequent dosing and enhancing patient compliance. Conclusion: Terminalia arjuna mediated SeNPs gel shows promise for more rapid and sustained drug delivery in the management of chronic periodontitis through local drug delivery systems. |
| format | Article |
| id | doaj-art-dc64c5c2733c4df1b7eec0fa440b7091 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-dc64c5c2733c4df1b7eec0fa440b70912025-02-09T05:00:12ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-01-01151199204Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro studyR. Vijayalakshmi0N. Ambalavanan1S. Rajeshkumar2Jaideep Mahendra3Uma Sudhakar4Devi Parameswari5Dept of Periodontology, Meenakshi Ammal Dental College & Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, India; Corresponding author.Dept of Periodontology, Meenakshi Ammal Dental College & Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, IndiaNanobiomedicine Lab, Saveetha Dental College & Hospital, SIMATS, Saveetha University, Chennai, IndiaDept of Periodontology, Meenakshi Ammal Dental College & Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, IndiaDepartment of Periodontology, Thai Moogambigai Dental College and Hospital, Nerkundram, Chennai, IndiaDept of Prosthodontics, Meenakshi Ammal Dental College & Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, Tamilnadu, IndiaBackground: This study compared the drug release kinetics of Terminalia arjuna mediated selenium nanoparticles (SeNPs) gel and zinc oxide nanoparticles (ZnONPs) gel for their potential in local drug delivery for chronic periodontitis. Material and method: The drug release was evaluated in-vitro by conducting tests on different formulations, including 1 %, 2 %, 3 %, 4 %, and 5 % Terminalia arjuna mediated SeNPs gel and ZnONPs gel. Each sample, approximately 0.1 mg, was mixed with 10 mL of phosphate buffer saline (PBS) at various pH levels and maintained at 37 °C. The suspension was then placed in an incubated shaker at 120 rpm for 1 h. Five-milliliter samples were withdrawn from the dissolution medium at 30-min intervals and replaced with fresh PBS buffer to maintain a constant volume. The released drug amount was measured using a UV spectrophotometer (Systronics, India) at 290 nm. Result: The investigation revealed that SeNPs gel exhibited higher drug release percentages compared to ZnONPs gel across various concentrations and time points. The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. The near-complete release of the drug at 500 min highlights the potential for prolonged therapeutic efficacy, reducing the need for frequent dosing and enhancing patient compliance. Conclusion: Terminalia arjuna mediated SeNPs gel shows promise for more rapid and sustained drug delivery in the management of chronic periodontitis through local drug delivery systems.http://www.sciencedirect.com/science/article/pii/S2212426824001878Terminalia arjunaGreen synthesisTerminalia arjuna mediated SeNPs gelTerminalia arjuna mediated ZnONPs gel |
| spellingShingle | R. Vijayalakshmi N. Ambalavanan S. Rajeshkumar Jaideep Mahendra Uma Sudhakar Devi Parameswari Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study Journal of Oral Biology and Craniofacial Research Terminalia arjuna Green synthesis Terminalia arjuna mediated SeNPs gel Terminalia arjuna mediated ZnONPs gel |
| title | Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study |
| title_full | Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study |
| title_fullStr | Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study |
| title_full_unstemmed | Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study |
| title_short | Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study |
| title_sort | comparative drug release kinetics of terminalia arjuna mediated senps nanogel and znonps nanogel an in vitro study |
| topic | Terminalia arjuna Green synthesis Terminalia arjuna mediated SeNPs gel Terminalia arjuna mediated ZnONPs gel |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824001878 |
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