NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions
The oxidation of sulfide substrate in one of the synthetic stages of Polmacoxib drug substance has been efficiently performed employing cost efficient NaNO2-HCl reagents in phase transfer catalyst TBAB containing biphasic MDC-Water reaction media at 0-5 °C temperature to afford sulfoxide intermedia...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2024-12-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
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| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/18740 |
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| author | Macchindra Kadam Deepak Nale Datta Thorat Venkateswara Rao Vallu Bollikonda Satyanarayana Padi Pratap Reddy Sayujjata R. Vaidya |
| author_facet | Macchindra Kadam Deepak Nale Datta Thorat Venkateswara Rao Vallu Bollikonda Satyanarayana Padi Pratap Reddy Sayujjata R. Vaidya |
| author_sort | Macchindra Kadam |
| collection | DOAJ |
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The oxidation of sulfide substrate in one of the synthetic stages of Polmacoxib drug substance has been efficiently performed employing cost efficient NaNO2-HCl reagents in phase transfer catalyst TBAB containing biphasic MDC-Water reaction media at 0-5 °C temperature to afford sulfoxide intermediate (1A) as an only product. The formed products were characterized by techniques such as NMR, MS and IR spectroscopy. To the best of our knowledge, the present work is the first report on utilization of NaNO2/TBAB/HCl catalytic system for the preparation of Polmacoxib stage 1A intermediate. Cost and energy efficiency, use of commercially available catalysts, high yields and purity are merits of the present work.
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| format | Article |
| id | doaj-art-dc63f193754b4f65854c30c29aa89ce9 |
| institution | Kabale University |
| issn | 1984-6428 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj-art-dc63f193754b4f65854c30c29aa89ce92025-01-11T14:34:09ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282024-12-0116410.17807/orbital.v16i4.18740NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions Macchindra Kadam0Deepak Nale1Datta Thorat2Venkateswara Rao Vallu3Bollikonda Satyanarayana4Padi Pratap Reddy5Sayujjata R. Vaidya6Chemical Research and Development, Macleods Pharmaceuticals Ltd., Plot No-124, Road No. 17, MIDC, Marol Industrial Area, Andheri East, Mumbai 400 093, Maharashtra, India.Institute of chemical technologyChemical Research and Development, Macleods Pharmaceuticals Ltd., Plot No-124, Road No. 17, MIDC, Marol Industrial Area, Andheri East, Mumbai 400 093, Maharashtra, India.Chemical Research and Development, Macleods Pharmaceuticals Ltd., Plot No-124, Road No. 17, MIDC, Marol Industrial Area, Andheri East, Mumbai 400 093, Maharashtra, India.Chemical Research and Development, Macleods Pharmaceuticals Ltd., Plot No-124, Road No. 17, MIDC, Marol Industrial Area, Andheri East, Mumbai 400 093, Maharashtra, India.Chemical Research and Development, Macleods Pharmaceuticals Ltd., Plot No-124, Road No. 17, MIDC, Marol Industrial Area, Andheri East, Mumbai 400 093, Maharashtra, India.Department of Chemistry, Vivekanand Arts, Sardar Dalipsingh Commerce and Science college, Samarth Nagar, Aurangabad 431 004, Maharashtra, India. The oxidation of sulfide substrate in one of the synthetic stages of Polmacoxib drug substance has been efficiently performed employing cost efficient NaNO2-HCl reagents in phase transfer catalyst TBAB containing biphasic MDC-Water reaction media at 0-5 °C temperature to afford sulfoxide intermediate (1A) as an only product. The formed products were characterized by techniques such as NMR, MS and IR spectroscopy. To the best of our knowledge, the present work is the first report on utilization of NaNO2/TBAB/HCl catalytic system for the preparation of Polmacoxib stage 1A intermediate. Cost and energy efficiency, use of commercially available catalysts, high yields and purity are merits of the present work. https://periodicos.ufms.br/index.php/orbital/article/view/18740NSAIDsOxidationPharmaceuticalsPhase transfer catalystPolmacoxibProcess chemistry |
| spellingShingle | Macchindra Kadam Deepak Nale Datta Thorat Venkateswara Rao Vallu Bollikonda Satyanarayana Padi Pratap Reddy Sayujjata R. Vaidya NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions Orbital: The Electronic Journal of Chemistry NSAIDs Oxidation Pharmaceuticals Phase transfer catalyst Polmacoxib Process chemistry |
| title | NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions |
| title_full | NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions |
| title_fullStr | NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions |
| title_full_unstemmed | NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions |
| title_short | NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions |
| title_sort | nano2 hcl tbab catalyst a controlled aerobic oxidation of sulfide substrate in the preparation of polmacoxib intermediate under mild conditions |
| topic | NSAIDs Oxidation Pharmaceuticals Phase transfer catalyst Polmacoxib Process chemistry |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/18740 |
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