The effect of beta-globin intron and WPRE on transient expression of SARS-CoV-2 spike and generation of pseudotyped lentiviruses

The effect of beta-globin intron and WPRE on transient expression of SARS-CoV-2 spike and generation of pseudotyped lentiviruses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an enveloped, single-stranded RNA virus, is causative of coronavirus disease 2019 (COVID-19). The viral entry process is facilitated by the highly antigenic spike protein of SARS-CoV-2, which binds to the angiotensin-converting enzyme 2 (...

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Bibliographic Details
Main Authors: Hyeop Jin, Ye Rae Cho, Yong Tae Jung
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Acta Virologica
Subjects:
β-globin intron
COVID-19
pseudovirus
Sars-CoV-2
WPRE
Online Access:https://www.frontierspartnerships.org/articles/10.3389/av.2025.14262/full
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