Modeling a biofluid-derived extracellular vesicle surface signature to differentiate pediatric idiopathic nephrotic syndrome clinical subgroups

Modeling a biofluid-derived extracellular vesicle surface signature to differentiate pediatric idiopathic nephrotic syndrome clinical subgroups

Abstract Idiopathic Nephrotic Syndrome (INS) is a common childhood glomerular disease requiring intense immunosuppressive drug treatments. Prediction of treatment response and the occurrence of relapses remains challenging. Biofluid-derived extracellular vesicles (EVs) may serve as novel liquid biop...

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Bibliographic Details
Main Authors: Giulia Cricri, Andrea Gobbini, Stefania Bruno, Linda Bellucci, Sarah Tassinari, Federico Caicci, Chiara Tamburello, Teresa Nittoli, Irene Paraboschi, Alfredo Berrettini, Renata Grifantini, Benedetta Bussolati, William Morello, Giovanni Montini, Federica Collino
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Idiopathic nephrotic syndrome
Extracellular vesicles
Protein biomarkers
Steroid resistance
Online Access:https://doi.org/10.1038/s41598-024-76727-w
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