Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice
Conclusion: Juglans regia L.’s hydroalcoholic extract possesses antiasthmatic activity by normalizing the TLC cells and DLC cells. Juglans regia L.’s hydroalcoholic extract resulted in the amelioration of pulmonary edema which is attributed to the upregulation of HO-1, occludin, and ZO-1 in the lung...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/jotm/6976932 |
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| author | Neelam Arshed Arham Shabbir Humaira Majeed Khan Tabinda Fatima Esraa M. Haji Farhan K. Alswailmi Ali F. Almutairy Ashfaq Ahmad |
| author_facet | Neelam Arshed Arham Shabbir Humaira Majeed Khan Tabinda Fatima Esraa M. Haji Farhan K. Alswailmi Ali F. Almutairy Ashfaq Ahmad |
| author_sort | Neelam Arshed |
| collection | DOAJ |
| description | Conclusion: Juglans regia L.’s hydroalcoholic extract possesses antiasthmatic activity by normalizing the TLC cells and DLC cells. Juglans regia L.’s hydroalcoholic extract resulted in the amelioration of pulmonary edema which is attributed to the upregulation of HO-1, occludin, and ZO-1 in the lung tissues of the Juglans regia L. treated groups when compared to the diseased control group. Administration of Juglans regia L.’s extract also reduces the scores of inflammation and vascular congestion by evaluation of the lungs’ histopathology in the disease control group when compared to the NC group. |
| format | Article |
| id | doaj-art-dc592998a8664f6c804e2dd4457aa73c |
| institution | OA Journals |
| issn | 1687-9694 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-dc592998a8664f6c804e2dd4457aa73c2025-08-20T01:57:15ZengWileyJournal of Tropical Medicine1687-96942025-01-01202510.1155/jotm/6976932Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic MiceNeelam Arshed0Arham Shabbir1Humaira Majeed Khan2Tabinda Fatima3Esraa M. Haji4Farhan K. Alswailmi5Ali F. Almutairy6Ashfaq Ahmad7Department of PharmacologyDepartment of PharmacologyDepartment of PharmacologyDepartment of Pharmaceutical ChemistryDepartment of Pharmaceutical ChemistryDepartment of Pharmacy PracticeDepartment of Pharmacology and ToxicologyDepartment of Pharmacy PracticeConclusion: Juglans regia L.’s hydroalcoholic extract possesses antiasthmatic activity by normalizing the TLC cells and DLC cells. Juglans regia L.’s hydroalcoholic extract resulted in the amelioration of pulmonary edema which is attributed to the upregulation of HO-1, occludin, and ZO-1 in the lung tissues of the Juglans regia L. treated groups when compared to the diseased control group. Administration of Juglans regia L.’s extract also reduces the scores of inflammation and vascular congestion by evaluation of the lungs’ histopathology in the disease control group when compared to the NC group.http://dx.doi.org/10.1155/jotm/6976932 |
| spellingShingle | Neelam Arshed Arham Shabbir Humaira Majeed Khan Tabinda Fatima Esraa M. Haji Farhan K. Alswailmi Ali F. Almutairy Ashfaq Ahmad Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice Journal of Tropical Medicine |
| title | Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice |
| title_full | Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice |
| title_fullStr | Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice |
| title_full_unstemmed | Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice |
| title_short | Juglans regia L. (Walnut) Leaf Extract Ameliorates Pulmonary Edema Against Airway Inflammation via Upregulation of Tight Junction Proteins and Heme Oxygenase-1 in the Lungs of Asthmatic Mice |
| title_sort | juglans regia l walnut leaf extract ameliorates pulmonary edema against airway inflammation via upregulation of tight junction proteins and heme oxygenase 1 in the lungs of asthmatic mice |
| url | http://dx.doi.org/10.1155/jotm/6976932 |
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