20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1

20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1

Currently, intensive chemotherapy with cytarabine and anthracycline (the “7 + 3” regimen) and hypomethylating agents remains the standard treatment for patients with acute myeloid leukemia (AML). Despite advances in treatment such as targeted therapies, patient outcomes remain unsatisfactory due to...

Full description

Saved in:
Bibliographic Details
Main Authors: Meng Xu, Feng Hao, Shuangshuang Wu, Zhanning Qu, Junying Li, Shuang Chen, Fang Fang, Yundong Zhao, Cheng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
acute myeloid leukemia
20(S)-protopanaxadiol
MCL-1
Bcl-XL
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530270/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items