A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia
Staphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infectio...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2011/725483 |
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| author | Gowrisankar Rajam Gabrielle M. Hammons George M. Carlone Jacquelyn S. Sampson Edwin W. Ades |
| author_facet | Gowrisankar Rajam Gabrielle M. Hammons George M. Carlone Jacquelyn S. Sampson Edwin W. Ades |
| author_sort | Gowrisankar Rajam |
| collection | DOAJ |
| description | Staphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infections with limited success. In this study, we demonstrate that P4, a 28-amino acid peptide, derived from pneumococcal surface adhesin A along with pathogen-specific antibody (IVIG; P4 therapy) is successful in enhancing the opsonophagocytic killing (OPK) of S. aureus in vitro. We questioned if it is possible to expand P4 therapy to treat staphylococcal infections in vivo. P4 therapy in combination with IVIG rescued 7/10 morbidly ill S. aureus-infected mice while only 2/10 survived in the control group. |
| format | Article |
| id | doaj-art-dc576e98fbee42d597770bc5849cc3dd |
| institution | DOAJ |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-dc576e98fbee42d597770bc5849cc3dd2025-08-20T03:23:56ZengWileyInternational Journal of Microbiology1687-918X1687-91982011-01-01201110.1155/2011/725483725483A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus SepticemiaGowrisankar Rajam0Gabrielle M. Hammons1George M. Carlone2Jacquelyn S. Sampson3Edwin W. Ades4Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAStaphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infections with limited success. In this study, we demonstrate that P4, a 28-amino acid peptide, derived from pneumococcal surface adhesin A along with pathogen-specific antibody (IVIG; P4 therapy) is successful in enhancing the opsonophagocytic killing (OPK) of S. aureus in vitro. We questioned if it is possible to expand P4 therapy to treat staphylococcal infections in vivo. P4 therapy in combination with IVIG rescued 7/10 morbidly ill S. aureus-infected mice while only 2/10 survived in the control group.http://dx.doi.org/10.1155/2011/725483 |
| spellingShingle | Gowrisankar Rajam Gabrielle M. Hammons George M. Carlone Jacquelyn S. Sampson Edwin W. Ades A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia International Journal of Microbiology |
| title | A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia |
| title_full | A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia |
| title_fullStr | A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia |
| title_full_unstemmed | A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia |
| title_short | A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia |
| title_sort | novel innate immune enhancement strategy combined with ivig rescues mice from fatal staphylococcus aureus septicemia |
| url | http://dx.doi.org/10.1155/2011/725483 |
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