Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential
Oral cancer represents a major global health concern, characterized by high mortality rates attributed to late diagnosis and the constraints of traditional treatment methods. Chemotherapeutic, and radiotherapeutic methods frequently lead to significant side effects, elevated recurrence rates, and in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625000517 |
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| author | Nurhasni Hasan Maryam Aftab Muneeb Ullah Phuong Tram Nguyen Rina Agustina Yulia Yusrini Djabir Theofilus A. Tockary Satoshi Uchida |
| author_facet | Nurhasni Hasan Maryam Aftab Muneeb Ullah Phuong Tram Nguyen Rina Agustina Yulia Yusrini Djabir Theofilus A. Tockary Satoshi Uchida |
| author_sort | Nurhasni Hasan |
| collection | DOAJ |
| description | Oral cancer represents a major global health concern, characterized by high mortality rates attributed to late diagnosis and the constraints of traditional treatment methods. Chemotherapeutic, and radiotherapeutic methods frequently lead to significant side effects, elevated recurrence rates, and inadequate targeting. Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. Nanoparticles, encompassing organic, inorganic, and hybrid types (combined organic and inorganic materials), are investigated for their distinct properties in targeted drug delivery, with the objective of addressing existing therapeutic challenges. Despite encouraging preclinical results, issues related to nanoparticle stability, safety, and regulatory considerations remain, necessitating additional research to connect experimental outcomes with clinical applications. |
| format | Article |
| id | doaj-art-dc4f0eebbd174c85b0eb5b978c3fa759 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-dc4f0eebbd174c85b0eb5b978c3fa7592025-02-05T04:31:55ZengElsevierResults in Chemistry2211-71562025-03-0114102068Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potentialNurhasni Hasan0Maryam Aftab1Muneeb Ullah2Phuong Tram Nguyen3Rina Agustina4Yulia Yusrini Djabir5Theofilus A. Tockary6Satoshi Uchida7Faculty of Pharmacy, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km 10, Makassar 90245, Republic of Indonesia; Corresponding author at: Faculty of Pharmacy, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km 10, Makassar 90245, Republic of Indonesia.Department of Biosciences, COMSATS University, Park Road, 45520 Islamabad, PakistanCollege of Pharmacy, Pusan National University, Busandaehak-ro 63 beon-gil 2, Geoumjeong-gu, Busan 46241, Republic of KoreaFaculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, VietnamFaculty of Pharmacy, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km 10, Makassar 90245, Republic of IndonesiaFaculty of Pharmacy, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km 10, Makassar 90245, Republic of IndonesiaInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, JapanInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan; Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science, Tokyo 113-8510, JapanOral cancer represents a major global health concern, characterized by high mortality rates attributed to late diagnosis and the constraints of traditional treatment methods. Chemotherapeutic, and radiotherapeutic methods frequently lead to significant side effects, elevated recurrence rates, and inadequate targeting. Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. Nanoparticles, encompassing organic, inorganic, and hybrid types (combined organic and inorganic materials), are investigated for their distinct properties in targeted drug delivery, with the objective of addressing existing therapeutic challenges. Despite encouraging preclinical results, issues related to nanoparticle stability, safety, and regulatory considerations remain, necessitating additional research to connect experimental outcomes with clinical applications.http://www.sciencedirect.com/science/article/pii/S2211715625000517Oral cancerNanoparticlesTargeted therapyDrug deliveryBioavailability |
| spellingShingle | Nurhasni Hasan Maryam Aftab Muneeb Ullah Phuong Tram Nguyen Rina Agustina Yulia Yusrini Djabir Theofilus A. Tockary Satoshi Uchida Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential Results in Chemistry Oral cancer Nanoparticles Targeted therapy Drug delivery Bioavailability |
| title | Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential |
| title_full | Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential |
| title_fullStr | Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential |
| title_full_unstemmed | Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential |
| title_short | Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential |
| title_sort | nanoparticle based drug delivery system for oral cancer mechanism challenges and therapeutic potential |
| topic | Oral cancer Nanoparticles Targeted therapy Drug delivery Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625000517 |
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