CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma

CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma

IntroductionCAR-T cell therapy, though successful in hematologic malignancies, faces challenges in solid tumors due to limitations of autologous T cells. Cytokine-induced killer (CIK) cells can be given safely across allogeneic barriers and constitute alternative effector cells generated from health...

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Bibliographic Details
Main Authors: Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Michael Merker, Christian Münch, Elise Gradhand, Meike Vogler, Evelyn Ullrich, Halvard Bönig, Jan-Henning Klusmann, Peter Bader, Winfried S. Wels, Eva Rettinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
cytokine-induced killer cells (CIK)
CAR-T
rhabdomyosarcoma
solid tumors
ERBB2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1485817/full
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