Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling

Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling

Background: Alcohol-related brain damage (ARBD) causes cognitive-behavioral impairments that can lead to dementia. White matter is a major target in ARBD. Additional research is needed to better understand the mechanisms of ARBD progression to advanced stages with permanent disability. Potential con...

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Bibliographic Details
Main Authors: Ming Tong, Camilla Homans, William Pelit, Busra Delikkaya, Suzanne M. de la Monte
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
alcohol-related brain damage
white matter
rat model
mTOR
oligodendrocytes
Online Access:https://www.mdpi.com/2218-273X/15/3/413
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