Exosome-delivered METTL14 drives hypoxia-induced proliferation, metastasis, and glycolysis of breast cancer cells through regulating TRIM16-mediated FGF7 ubiquitination

Exosome-delivered METTL14 drives hypoxia-induced proliferation, metastasis, and glycolysis of breast cancer cells through regulating TRIM16-mediated FGF7 ubiquitination

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and has a poor prognosis. Previous studies have indicated that Fibroblast Growth Factor 7 (FGF7) plays a vital role in the development and progression of breast cancer. However, the role and molecular mec...

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Bibliographic Details
Main Authors: Bo Huang, Yichao Zhang, Zhanjun Chen, Yuanyuan Yuan, Jianshan Lin
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Breast Cancer Research
Subjects:
Hypoxia
TNBC
FGF7
TRIM16
METTL14
Proliferation
Online Access:https://doi.org/10.1186/s13058-025-02099-2
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