Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer
Background and purpose: Tumor microangiogenesis is an important basis for tumor growth and metastasis, and its characteristics include angiogenesis, increased vascular permeability and abnormal capillary structure. Microangiogenesis not only affects the blood supply and metabolism of tumor, but also...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of China Oncology
2025-03-01
|
| Series: | Zhongguo aizheng zazhi |
| Subjects: | |
| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/1744268636315-1234299746.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850194884243226624 |
|---|---|
| author | SONG Dan, CHAI Yaxin, GE Yanping |
| author_facet | SONG Dan, CHAI Yaxin, GE Yanping |
| author_sort | SONG Dan, CHAI Yaxin, GE Yanping |
| collection | DOAJ |
| description | Background and purpose: Tumor microangiogenesis is an important basis for tumor growth and metastasis, and its characteristics include angiogenesis, increased vascular permeability and abnormal capillary structure. Microangiogenesis not only affects the blood supply and metabolism of tumor, but also is directly related to the invasion, prognosis and treatment response of tumor. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive imaging technique. By quantitatively analyzing the distribution and dynamic changes of contrast agents in tumor tissues, it can reflect the microvascular density (MVD), permeability and blood perfusion of tumors. The purpose of this study was to further clarify the application value of DCE-MRI in the diagnosis and treatment of rectal cancer by in-depth analysis of the relationship between quantitative analysis parameters of rectal cancer and microangiogenesis, and to promote the popularization and optimization of this technology in clinical practice. Methods: A total of 348 patients with rectal cancer who were scheduled for surgical treatment in Xinxiang Central Hospital from January 2021 to June 2024 were selected, and rectal cancer tissue specimens and adjacent tissues (> 5 cm away from tumor margin) were collected. This study was approved by the medical ethics committee of Xinxiang Central Hospital (approval number: 2021-144-01K). The quantitative analysis parameters of DCE-MRI [Rate constant (Kep), volume transport constant (Ktrans), volume fraction of contrast agent in extracellular space (VE)] and MVD in cancer tissues and adjacent tissues were compared. The quantitative analysis parameters and MVD of DCE-MRI in rectal cancer patients with different differentiation degrees and clinical stages were compared. Spearman correlation was used to analyze the correlation between DCE-MRI parameters and differentiation degree, clinical stage and MVD in patients with rectal cancer. Results: The values of Kep value, Ktrans value, Ve value and MVD were higher in rectal cancer tissues than in adjacent tissues (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with low differentiated and middle differentiated rectal cancer were higher than those of patients with high differentiated rectal cancer (P<0.05). The values of Kep value, Ktrans value, Ve value and MVD of patients with low differentiated rectal cancer were higher than those of patients with middle differentiated rectal cancer (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅱ, Ⅲ and Ⅳ rectal cancer were higher than those of patients with stage Ⅰ rectal cancer (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅲ and Ⅳ rectal cancer were higher than those of patients with stage Ⅱ rectal cancer (P <0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅳ rectal cancer were higher than those of patients with stage Ⅲ rectal cancer (P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were negatively correlated with the differentiation degree (r=-0.683, -0.743, -0.721, P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were positively correlated with clinical stage (r=0.764, 0.703, 0.814, P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were positively correlated with MVD (r=0.812, 0.754, 0.835, P<0.05). Conclusion: DCE-MRI parameters are related to the differentiation degree, clinical stage and microangiogenesis of rectal cancer. |
| format | Article |
| id | doaj-art-dc3d8cabaa3041df982257d851bbfc83 |
| institution | OA Journals |
| issn | 1007-3639 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj-art-dc3d8cabaa3041df982257d851bbfc832025-08-20T02:13:54ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392025-03-0135332032510.19401/j.cnki.1007-3639.2025.03.008Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancerSONG Dan, CHAI Yaxin, GE Yanping0Department of Magnetic Resonance Imaging, Xinxiang Central Hospital (the Fourth Clinical College, Xinxiang Medical University), Xinxiang 453000, Henan Province, ChinaBackground and purpose: Tumor microangiogenesis is an important basis for tumor growth and metastasis, and its characteristics include angiogenesis, increased vascular permeability and abnormal capillary structure. Microangiogenesis not only affects the blood supply and metabolism of tumor, but also is directly related to the invasion, prognosis and treatment response of tumor. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive imaging technique. By quantitatively analyzing the distribution and dynamic changes of contrast agents in tumor tissues, it can reflect the microvascular density (MVD), permeability and blood perfusion of tumors. The purpose of this study was to further clarify the application value of DCE-MRI in the diagnosis and treatment of rectal cancer by in-depth analysis of the relationship between quantitative analysis parameters of rectal cancer and microangiogenesis, and to promote the popularization and optimization of this technology in clinical practice. Methods: A total of 348 patients with rectal cancer who were scheduled for surgical treatment in Xinxiang Central Hospital from January 2021 to June 2024 were selected, and rectal cancer tissue specimens and adjacent tissues (> 5 cm away from tumor margin) were collected. This study was approved by the medical ethics committee of Xinxiang Central Hospital (approval number: 2021-144-01K). The quantitative analysis parameters of DCE-MRI [Rate constant (Kep), volume transport constant (Ktrans), volume fraction of contrast agent in extracellular space (VE)] and MVD in cancer tissues and adjacent tissues were compared. The quantitative analysis parameters and MVD of DCE-MRI in rectal cancer patients with different differentiation degrees and clinical stages were compared. Spearman correlation was used to analyze the correlation between DCE-MRI parameters and differentiation degree, clinical stage and MVD in patients with rectal cancer. Results: The values of Kep value, Ktrans value, Ve value and MVD were higher in rectal cancer tissues than in adjacent tissues (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with low differentiated and middle differentiated rectal cancer were higher than those of patients with high differentiated rectal cancer (P<0.05). The values of Kep value, Ktrans value, Ve value and MVD of patients with low differentiated rectal cancer were higher than those of patients with middle differentiated rectal cancer (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅱ, Ⅲ and Ⅳ rectal cancer were higher than those of patients with stage Ⅰ rectal cancer (P<0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅲ and Ⅳ rectal cancer were higher than those of patients with stage Ⅱ rectal cancer (P <0.05). The Kep value, Ktrans value, Ve value and MVD of patients with stage Ⅳ rectal cancer were higher than those of patients with stage Ⅲ rectal cancer (P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were negatively correlated with the differentiation degree (r=-0.683, -0.743, -0.721, P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were positively correlated with clinical stage (r=0.764, 0.703, 0.814, P<0.05). The Kep value, Ktrans value and Ve value of rectal cancer patients were positively correlated with MVD (r=0.812, 0.754, 0.835, P<0.05). Conclusion: DCE-MRI parameters are related to the differentiation degree, clinical stage and microangiogenesis of rectal cancer.http://www.china-oncology.com/fileup/1007-3639/PDF/1744268636315-1234299746.pdf|rectal cancer|dynamic contrast-enhanced magnetic resonance imaging|quantitative parameters|degree of differentiation|clinical staging|microangiogenesis |
| spellingShingle | SONG Dan, CHAI Yaxin, GE Yanping Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer Zhongguo aizheng zazhi |rectal cancer|dynamic contrast-enhanced magnetic resonance imaging|quantitative parameters|degree of differentiation|clinical staging|microangiogenesis |
| title | Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer |
| title_full | Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer |
| title_fullStr | Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer |
| title_full_unstemmed | Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer |
| title_short | Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer |
| title_sort | relationship between quantitative analysis parameters of dce mri and microangiogenesis in rectal cancer |
| topic | |rectal cancer|dynamic contrast-enhanced magnetic resonance imaging|quantitative parameters|degree of differentiation|clinical staging|microangiogenesis |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/1744268636315-1234299746.pdf |
| work_keys_str_mv | AT songdanchaiyaxingeyanping relationshipbetweenquantitativeanalysisparametersofdcemriandmicroangiogenesisinrectalcancer |