Activation of cellular immune responses using a dengue tetravalent subunit DNA vaccine candidate with different cytokines as adjuvants

Activation of cellular immune responses using a dengue tetravalent subunit DNA vaccine candidate with different cytokines as adjuvants

Dengue remains a critical public health issue in endemic areas, with four co-circulating serotypes (DENV-1–4) and no widely accessible vaccine in Brazil. DNA vaccines offer logistical and cost advantages, and cytokine adjuvants may enhance immunogenicity. We engineered a tetravalent DNA vaccine enco...

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Bibliographic Details
Main Authors: Luciana de Souza Fernandes, Carine Ribeiro Pessoa, Roberto Sousa Dias, Cynthia Canedo da Silva, Sérgio Oliveira de Paula
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Vaccine: X
Subjects:
Dengue virus
DNA vaccine
Genetic adjuvants
Cytokines
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136225000993
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