Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors

Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors

Background Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform treatment decisions.Methods A de-identified pan-ca...

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Main Authors: Yan Liu, Matthew Zibelman, Timothy Chan, Justin Guinney, Douglas Adkins, Ezra E W Cohen, Michelle M Stein, Halla Nimeiri, Sandip P Patel, Alia D Zander, Rossin Erbe, Ailin Jin, Sayantoni Mukhopadhyay, Ben Terdich, Mario G Rosasco, Nirali Patel, Chithra Sangli, Timothy Taxter, Seung Won Hyun, Brett M Mahon, A Kate Sasser, Michelle A Ting-Lin, Kyle A Beauchamp
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e011363.full
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