Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

Abstract COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has been adapted to XBB.1.5 and JN.1 variants, as monoval...

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Main Authors: Laura A. Bruno, Celeste Pueblas Castro, Agostina Demaría, Lineia Prado, Clara G. Fascetto Cassero, Lucas M. Saposnik, Federico Páez Córdoba, Juan Manuel Rodriguez, Giulia Piccini, Roberta Antonelli, Giulia Lapini, Nigel Temperton, Sabrina A. Del Priore, Andres C. Hernando Insua, Ingrid G. Kaufmann, Julio C. Vega, Juan M. Flo, Karina A. Pasquevich, Lorena M. Coria, Juliana Cassataro
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01156-3
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