Metabolomic profiles in serum uncover novel biomarkers in children with Williams–Beuren syndrome

Metabolomic profiles in serum uncover novel biomarkers in children with Williams–Beuren syndrome

Abstract Williams–Beuren syndrome (WBS, OMIM-no.194050) is a rare congenital genetic disorder primarily marked by developmental delays and cardiovascular anomalies, with potential involvement of metabolic dysregulation. Despite this, the metabolic features of WBS have not been extensively studied. T...

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Bibliographic Details
Main Authors: Guannan Bai, Weijun Chen, Chai Ji, Yang Yang, Jiyang Shen, Fangfang Li, Yang Wen, Danny Junyi Tan, Xiaoling Jiang, Yingping Xiao, Jinluan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Williams–Beuren syndrome
Untargeted metabolomics
Serotonin
Tryptophan
Retrograde endocannabinoid signaling
Bile acids
Online Access:https://doi.org/10.1038/s41598-025-94018-w
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