Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites
The gut microbiota and it’s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia, which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2025-07-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250305 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850033508304551936 |
|---|---|
| author | Yu Wang Xinyue Xing Yamei He Yue Zhang Yuxuan Ma Bo Nan Li Xia Yuhua Wang Jingsheng Liu |
| author_facet | Yu Wang Xinyue Xing Yamei He Yue Zhang Yuxuan Ma Bo Nan Li Xia Yuhua Wang Jingsheng Liu |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | The gut microbiota and it’s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia, which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota and it’s metabolites directly, the rebalanced intestinal flora mediated by PP04 could facilitate the secretion of short chain fatty acids to control body weight gain, PP04 intervention also changed bile acid (BA) profiles and enhanced the ileal concentrations of antagonists including tauro-α/β-muricholic acid sodium salt and ursodeoxycholic acid to inhibit intestinal farnesoid X receptor/fibroblast growth factor 15 (FXR/FGF15) signaling coupled with the activation of hepatic FXR/small heterodimer partners signaling, which accelerated the hepatic BA de novo synthesis and excretion with feces to eliminate HFD caused hyperlipemia effectively. This study provided important evidence regarding PP04 as dietary supplement to relieve hyperlipidemia by influencing BA enterohepatic circulation. |
| format | Article |
| id | doaj-art-dc30144536b344b399fc9a1b130b2e9d |
| institution | DOAJ |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-dc30144536b344b399fc9a1b130b2e9d2025-08-20T02:58:11ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-07-01147925030510.26599/FSHW.2024.9250305Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolitesYu Wang0Xinyue Xing1Yamei He2Yue Zhang3Yuxuan Ma4Bo Nan5Li Xia6Yuhua Wang7Jingsheng Liu8College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaThe gut microbiota and it’s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia, which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota and it’s metabolites directly, the rebalanced intestinal flora mediated by PP04 could facilitate the secretion of short chain fatty acids to control body weight gain, PP04 intervention also changed bile acid (BA) profiles and enhanced the ileal concentrations of antagonists including tauro-α/β-muricholic acid sodium salt and ursodeoxycholic acid to inhibit intestinal farnesoid X receptor/fibroblast growth factor 15 (FXR/FGF15) signaling coupled with the activation of hepatic FXR/small heterodimer partners signaling, which accelerated the hepatic BA de novo synthesis and excretion with feces to eliminate HFD caused hyperlipemia effectively. This study provided important evidence regarding PP04 as dietary supplement to relieve hyperlipidemia by influencing BA enterohepatic circulation.https://www.sciopen.com/article/10.26599/FSHW.2024.9250305pediococcus pentosaceus pp04hyperlipidemiaintestinal florabile acidshort chain fatty acid |
| spellingShingle | Yu Wang Xinyue Xing Yamei He Yue Zhang Yuxuan Ma Bo Nan Li Xia Yuhua Wang Jingsheng Liu Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites Food Science and Human Wellness pediococcus pentosaceus pp04 hyperlipidemia intestinal flora bile acid short chain fatty acid |
| title | Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites |
| title_full | Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites |
| title_fullStr | Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites |
| title_full_unstemmed | Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites |
| title_short | Mechanism of Pediococcus pentosaceus PP04 in alleviating high-fat diet caused hyperlipidemia via modulation of intestinal flora and it's metabolites |
| title_sort | mechanism of pediococcus pentosaceus pp04 in alleviating high fat diet caused hyperlipidemia via modulation of intestinal flora and it s metabolites |
| topic | pediococcus pentosaceus pp04 hyperlipidemia intestinal flora bile acid short chain fatty acid |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250305 |
| work_keys_str_mv | AT yuwang mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT xinyuexing mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT yameihe mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT yuezhang mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT yuxuanma mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT bonan mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT lixia mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT yuhuawang mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites AT jingshengliu mechanismofpediococcuspentosaceuspp04inalleviatinghighfatdietcausedhyperlipidemiaviamodulationofintestinalfloraanditsmetabolites |