Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map
BackgroundThe use of extended reality (XR), including virtual reality (VR) and augmented reality (AR), for treating pain has accelerated in the last 10 years. XR is an attractive biobehavioral intervention that may support management of pain or pain-related disability. Review...
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JMIR Publications
2025-04-01
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| Series: | JMIR Pediatrics and Parenting |
| Online Access: | https://pediatrics.jmir.org/2025/1/e63854 |
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| author | Courtney W Hess Brittany N Rosenbloom Giulia Mesaroli Cristal Lopez Nhat Ngo Estreya Cohen Carley Ouellette Jeffrey I Gold Deirdre Logan Laura E Simons Jennifer N Stinson |
| author_facet | Courtney W Hess Brittany N Rosenbloom Giulia Mesaroli Cristal Lopez Nhat Ngo Estreya Cohen Carley Ouellette Jeffrey I Gold Deirdre Logan Laura E Simons Jennifer N Stinson |
| author_sort | Courtney W Hess |
| collection | DOAJ |
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BackgroundThe use of extended reality (XR), including virtual reality (VR) and augmented reality (AR), for treating pain has accelerated in the last 10 years. XR is an attractive biobehavioral intervention that may support management of pain or pain-related disability. Reviews of the literature pertaining to adults report promising results, particularly for acute procedural pain.
ObjectiveThis study aimed to (1) summarize the available evidence with respect to feasibility, safety, and effectiveness (pain intensity) of XR for pediatric acute and chronic pain; (2) summarize assessment tools used to measure study outcomes; and (3) identify gaps in evidence to guide future research efforts.
MethodsThis study is a systematic review of the literature. Multiple databases (CINAHL, Cochrane Central, Embase, MEDLINE, PsycINFO) were searched from inception until March 2023. Titles, abstracts, and full-text articles were reviewed by 2 team members to determine eligibility. Articles were included if the (1) participants were aged 0 to 18 years; (2) study intervention was VR or AR; (3) study outcomes included safety, feasibility, acceptability, or effectiveness on the outcome of pain; and (4) study design was observational or interventional. Data were collected on bibliographic information; study characteristics; XR characteristics; outcome domains; outcome measures; and study findings pertaining to safety, feasibility, and effectiveness.
ResultsWe included 90 articles in the review. All included studies used VR, and 93% (84/90) studied VR in the context of acute pain. Of the 90 studies, 74 studies were randomized trials, and 15 studies were observational. Safety was assessed in 23 studies of acute pain, with 13 studies reporting no adverse events and 10 studies reporting events of low concern. Feasibility was assessed in 27 studies. Of the 84 studies of acute pain, 62% (52/84) reported a positive effect on pain intensity, 21% (18/84) reported no effect, and 13% (11/84) reported mixed effects. All 6 studies of chronic pain reported a positive effect on pain intensity. An evidence gap map was used to illuminate gaps in specific research areas stratified by subtypes of pain. Risk of bias assessment revealed 67 studies had a moderate risk of bias, 17 studies had a high risk, and 5 studies were deemed to be low risk.
ConclusionsThe current body of literature around XR for pediatric pain is focused on acute pain with promising results of safety and effectiveness on pain intensity. The literature pertaining to chronic pain lags behind, limiting our ability to draw conclusions. The risk of bias in studies is problematic in this field, with the inherent challenge of blinding participants and researchers to the intervention. Future research should aim to measure effectiveness beyond pain intensity with a consistent approach to measuring key outcome domains and measures. Current efforts are underway to establish expert consensus on best research practices in this field.
Trial RegistrationProspero CRD42022307153; https://www.crd.york.ac.uk/PROSPERO/view/CRD42022307153 |
| format | Article |
| id | doaj-art-dc2e2aad105749c39dc4c69b717f1dbd |
| institution | OA Journals |
| issn | 2561-6722 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | JMIR Publications |
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| series | JMIR Pediatrics and Parenting |
| spelling | doaj-art-dc2e2aad105749c39dc4c69b717f1dbd2025-08-20T02:25:47ZengJMIR PublicationsJMIR Pediatrics and Parenting2561-67222025-04-018e6385410.2196/63854Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap MapCourtney W Hesshttps://orcid.org/0000-0001-5207-7411Brittany N Rosenbloomhttps://orcid.org/0000-0002-5881-4045Giulia Mesarolihttps://orcid.org/0000-0001-6583-5082Cristal Lopezhttps://orcid.org/0000-0002-1900-4365Nhat Ngohttps://orcid.org/0009-0000-7465-4531Estreya Cohenhttps://orcid.org/0000-0003-4645-8634Carley Ouellettehttps://orcid.org/0000-0003-3242-6164Jeffrey I Goldhttps://orcid.org/0000-0003-4493-1299Deirdre Loganhttps://orcid.org/0000-0002-9253-0097Laura E Simonshttps://orcid.org/0000-0002-3395-9483Jennifer N Stinsonhttps://orcid.org/0000-0002-9969-8052 BackgroundThe use of extended reality (XR), including virtual reality (VR) and augmented reality (AR), for treating pain has accelerated in the last 10 years. XR is an attractive biobehavioral intervention that may support management of pain or pain-related disability. Reviews of the literature pertaining to adults report promising results, particularly for acute procedural pain. ObjectiveThis study aimed to (1) summarize the available evidence with respect to feasibility, safety, and effectiveness (pain intensity) of XR for pediatric acute and chronic pain; (2) summarize assessment tools used to measure study outcomes; and (3) identify gaps in evidence to guide future research efforts. MethodsThis study is a systematic review of the literature. Multiple databases (CINAHL, Cochrane Central, Embase, MEDLINE, PsycINFO) were searched from inception until March 2023. Titles, abstracts, and full-text articles were reviewed by 2 team members to determine eligibility. Articles were included if the (1) participants were aged 0 to 18 years; (2) study intervention was VR or AR; (3) study outcomes included safety, feasibility, acceptability, or effectiveness on the outcome of pain; and (4) study design was observational or interventional. Data were collected on bibliographic information; study characteristics; XR characteristics; outcome domains; outcome measures; and study findings pertaining to safety, feasibility, and effectiveness. ResultsWe included 90 articles in the review. All included studies used VR, and 93% (84/90) studied VR in the context of acute pain. Of the 90 studies, 74 studies were randomized trials, and 15 studies were observational. Safety was assessed in 23 studies of acute pain, with 13 studies reporting no adverse events and 10 studies reporting events of low concern. Feasibility was assessed in 27 studies. Of the 84 studies of acute pain, 62% (52/84) reported a positive effect on pain intensity, 21% (18/84) reported no effect, and 13% (11/84) reported mixed effects. All 6 studies of chronic pain reported a positive effect on pain intensity. An evidence gap map was used to illuminate gaps in specific research areas stratified by subtypes of pain. Risk of bias assessment revealed 67 studies had a moderate risk of bias, 17 studies had a high risk, and 5 studies were deemed to be low risk. ConclusionsThe current body of literature around XR for pediatric pain is focused on acute pain with promising results of safety and effectiveness on pain intensity. The literature pertaining to chronic pain lags behind, limiting our ability to draw conclusions. The risk of bias in studies is problematic in this field, with the inherent challenge of blinding participants and researchers to the intervention. Future research should aim to measure effectiveness beyond pain intensity with a consistent approach to measuring key outcome domains and measures. Current efforts are underway to establish expert consensus on best research practices in this field. Trial RegistrationProspero CRD42022307153; https://www.crd.york.ac.uk/PROSPERO/view/CRD42022307153https://pediatrics.jmir.org/2025/1/e63854 |
| spellingShingle | Courtney W Hess Brittany N Rosenbloom Giulia Mesaroli Cristal Lopez Nhat Ngo Estreya Cohen Carley Ouellette Jeffrey I Gold Deirdre Logan Laura E Simons Jennifer N Stinson Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map JMIR Pediatrics and Parenting |
| title | Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map |
| title_full | Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map |
| title_fullStr | Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map |
| title_full_unstemmed | Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map |
| title_short | Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map |
| title_sort | extended reality xr in pediatric acute and chronic pain systematic review and evidence gap map |
| url | https://pediatrics.jmir.org/2025/1/e63854 |
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