Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients

Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients

Introduction. Schizophrenia (SZ) increases the level of cell death, leading to an increase in the concentration of circulating cell-free DNA (cfDNA). Ribosomal DNA (rDNA) contains many unmethylated CpG motifs that stimulate TLR9-MyD88-NF-κB signaling and the synthesis of proinflammatory cytokines. T...

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Main Authors: E. S. Ershova, E. M. Jestkova, A. V. Martynov, G. V. Shmarina, P. E. Umriukhin, L. V. Bravve, N. V. Zakharova, G. P. Kostyuk, D. V. Saveliev, M. D. Orlova, M. Bogush, S. I. Kutsev, N. N. Veiko, S. V. Kostyuk
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:International Journal of Genomics
Online Access:http://dx.doi.org/10.1155/2019/8390585
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