Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechan...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/1603758 |
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| _version_ | 1849683366869204992 |
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| author | Wenjie Zeng Jie Shen Tao Bo Liangxin Peng Hongbo Xu Moussa Ide Nasser Quan Zhuang Mingyi Zhao |
| author_facet | Wenjie Zeng Jie Shen Tao Bo Liangxin Peng Hongbo Xu Moussa Ide Nasser Quan Zhuang Mingyi Zhao |
| author_sort | Wenjie Zeng |
| collection | DOAJ |
| description | Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient’s intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications. |
| format | Article |
| id | doaj-art-dc2d6732a08244c2acbe5523be0f112b |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-dc2d6732a08244c2acbe5523be0f112b2025-08-20T03:23:56ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/16037581603758Cutting Edge: Probiotics and Fecal Microbiota Transplantation in ImmunomodulationWenjie Zeng0Jie Shen1Tao Bo2Liangxin Peng3Hongbo Xu4Moussa Ide Nasser5Quan Zhuang6Mingyi Zhao7Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaTransplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of Surgery of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaGuangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaTransplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaProbiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient’s intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications.http://dx.doi.org/10.1155/2019/1603758 |
| spellingShingle | Wenjie Zeng Jie Shen Tao Bo Liangxin Peng Hongbo Xu Moussa Ide Nasser Quan Zhuang Mingyi Zhao Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation Journal of Immunology Research |
| title | Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation |
| title_full | Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation |
| title_fullStr | Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation |
| title_full_unstemmed | Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation |
| title_short | Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation |
| title_sort | cutting edge probiotics and fecal microbiota transplantation in immunomodulation |
| url | http://dx.doi.org/10.1155/2019/1603758 |
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