Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease

Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease

Abstract Background This study aims to explore the role of autophagy-associated genes (ATG) and their epigenetic markers in the progression of mycobacterium tuberculosis (M. tb) infection, and to test the effects of de-methylation agents on macrophage functions against TB. Methods ATG expressions an...

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Main Authors: Yung-Che Chen, Ying-Tang Fang, Chao-Chien Wu, Tung-Ying Chao, Yi-Hsi Wang, Chia-Cheng Tseng, Sum-Yee Leung, Chiu-Ping Lee, Ting-Ya Wang, Po-Yuan Hsu, Jen-Chieh Chang, Meng-Chih Lin, Chang-Chun Hsiao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Respiratory Research
Subjects:
Pulmonary tuberculosis
Latent TB infection
Autophagy
LC3B
ATG5
p62
Online Access:https://doi.org/10.1186/s12931-025-03149-1
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