The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients
Abstract Purpose To assess the prognosis predictive value of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-meta-iodobenzylguanidine (MIBG) SPECT/CT in pretreatment neuroblastoma (NB) patients. Methods A total of 50 children (25 girls, 25 boys, median age 37 mont...
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BMC
2025-03-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-025-00858-0 |
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| author | Ziang Zhou Xu Yang Guanyun Wang Xiaoya Wang Jun Liu Yanfeng Xu Kan Ying Wei Wang Jigang Yang |
| author_facet | Ziang Zhou Xu Yang Guanyun Wang Xiaoya Wang Jun Liu Yanfeng Xu Kan Ying Wei Wang Jigang Yang |
| author_sort | Ziang Zhou |
| collection | DOAJ |
| description | Abstract Purpose To assess the prognosis predictive value of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-meta-iodobenzylguanidine (MIBG) SPECT/CT in pretreatment neuroblastoma (NB) patients. Methods A total of 50 children (25 girls, 25 boys, median age 37 months, range 1-102 months) with newly diagnosed NB, consecutively examined with pretherapeutic 123I-MIBG SPECT/CT between 2018 and 2024, were included in this retrospective study. The semi-quantitative metabolic parameters and activity of primary tumor were measured, including Tmax/Lmax, Tmean/Lmean, Tmax/Lmean, Tmax/Mmax, Tmean/Mmean and asphericity (ASP). The ratio was maximum or mean count of primary tumor, liver and muscle. Clinical data and image-related factors was recorded as well. The outcome endpoint was event-free survival (EFS). Independent predictors were identified through univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) and Kaplan Meier analysis with log-rank test for EFS were performed. Results Median follow-up was 42 months (range 2.5–74 months; 4 patients showed disease progression/relapse, 7 patients died). The univariate and multivariate Cox regression analysis demonstrated that bone/bone marrow metastasis [95% confidence interval (CI): 1.051, 18.570, p = 0.043], Tmax/Lmax (95% CI: 1.074, 1.459, p = 0.004) and ASP (95% CI: 2.618, 273.477, p = 0.006) were independent predictors of EFS. The Kaplan Meier survival analyses demonstrated that Tmax/Lmax undefined $$\:>$$ ]]>6 and ASP $$\:>$$ undefined]]>34% and with bone/bone marrow metastasis had worse outcomes. Conclusion In this exploratory study, pretherapeutic 123I-MIBG image-derived semi-quantitative metabolic parameters and tumor asphericity provided prognostic value for EFS in NB patients. Tmax/Lmax $$\:>$$ undefined]]>6 and ASP $$\:>$$ undefined]]>34%, along with the presence of bone/bone marrow metastasis, could be considered as supplementary factors alongside existing ones. |
| format | Article |
| id | doaj-art-dc2344fc2fff4cf99f0c41002a951dc9 |
| institution | DOAJ |
| issn | 1470-7330 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj-art-dc2344fc2fff4cf99f0c41002a951dc92025-08-20T03:04:53ZengBMCCancer Imaging1470-73302025-03-0125111010.1186/s40644-025-00858-0The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patientsZiang Zhou0Xu Yang1Guanyun Wang2Xiaoya Wang3Jun Liu4Yanfeng Xu5Kan Ying6Wei Wang7Jigang Yang8Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical UniversityAbstract Purpose To assess the prognosis predictive value of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-meta-iodobenzylguanidine (MIBG) SPECT/CT in pretreatment neuroblastoma (NB) patients. Methods A total of 50 children (25 girls, 25 boys, median age 37 months, range 1-102 months) with newly diagnosed NB, consecutively examined with pretherapeutic 123I-MIBG SPECT/CT between 2018 and 2024, were included in this retrospective study. The semi-quantitative metabolic parameters and activity of primary tumor were measured, including Tmax/Lmax, Tmean/Lmean, Tmax/Lmean, Tmax/Mmax, Tmean/Mmean and asphericity (ASP). The ratio was maximum or mean count of primary tumor, liver and muscle. Clinical data and image-related factors was recorded as well. The outcome endpoint was event-free survival (EFS). Independent predictors were identified through univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) and Kaplan Meier analysis with log-rank test for EFS were performed. Results Median follow-up was 42 months (range 2.5–74 months; 4 patients showed disease progression/relapse, 7 patients died). The univariate and multivariate Cox regression analysis demonstrated that bone/bone marrow metastasis [95% confidence interval (CI): 1.051, 18.570, p = 0.043], Tmax/Lmax (95% CI: 1.074, 1.459, p = 0.004) and ASP (95% CI: 2.618, 273.477, p = 0.006) were independent predictors of EFS. The Kaplan Meier survival analyses demonstrated that Tmax/Lmax undefined $$\:>$$ ]]>6 and ASP $$\:>$$ undefined]]>34% and with bone/bone marrow metastasis had worse outcomes. Conclusion In this exploratory study, pretherapeutic 123I-MIBG image-derived semi-quantitative metabolic parameters and tumor asphericity provided prognostic value for EFS in NB patients. Tmax/Lmax $$\:>$$ undefined]]>6 and ASP $$\:>$$ undefined]]>34%, along with the presence of bone/bone marrow metastasis, could be considered as supplementary factors alongside existing ones.https://doi.org/10.1186/s40644-025-00858-0NeuroblastomaSemi-quantitativePrognosis123I-MIBGAsphericity |
| spellingShingle | Ziang Zhou Xu Yang Guanyun Wang Xiaoya Wang Jun Liu Yanfeng Xu Kan Ying Wei Wang Jigang Yang The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients Cancer Imaging Neuroblastoma Semi-quantitative Prognosis 123I-MIBG Asphericity |
| title | The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients |
| title_full | The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients |
| title_fullStr | The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients |
| title_full_unstemmed | The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients |
| title_short | The prognostic significance of semi-quantitative metabolic parameters and tumoral metabolic activity based on 123I-MIBG SPECT/CT in pretreatment neuroblastoma patients |
| title_sort | prognostic significance of semi quantitative metabolic parameters and tumoral metabolic activity based on 123i mibg spect ct in pretreatment neuroblastoma patients |
| topic | Neuroblastoma Semi-quantitative Prognosis 123I-MIBG Asphericity |
| url | https://doi.org/10.1186/s40644-025-00858-0 |
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