Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases
Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidney, and lungs. Toxic effects of Cd include h...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2021/9564297 |
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| author | Suryakant Niture Minghui Lin Qi Qi John T. Moore Keith E. Levine Reshan A. Fernando Deepak Kumar |
| author_facet | Suryakant Niture Minghui Lin Qi Qi John T. Moore Keith E. Levine Reshan A. Fernando Deepak Kumar |
| author_sort | Suryakant Niture |
| collection | DOAJ |
| description | Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidney, and lungs. Toxic effects of Cd include hepatotoxicity, nephrotoxicity, pulmonary toxicity, and the development of various human cancers. Cd is also involved in the development and progression of fatty liver diseases and hepatocellular carcinoma. Cd affects liver function via modulation of cell survival/proliferation, differentiation, and apoptosis. Moreover, Cd dysregulates hepatic autophagy, an endogenous catabolic process that detoxifies damaged cell organelles or dysfunctional cytosolic proteins through vacuole-mediated sequestration and lysosomal degradation. In this article, we review recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level. |
| format | Article |
| id | doaj-art-dc2323d852eb42099b09ec0967ee819f |
| institution | DOAJ |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-dc2323d852eb42099b09ec0967ee819f2025-08-20T03:23:56ZengWileyJournal of Toxicology1687-81911687-82052021-01-01202110.1155/2021/95642979564297Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver DiseasesSuryakant Niture0Minghui Lin1Qi Qi2John T. Moore3Keith E. Levine4Reshan A. Fernando5Deepak Kumar6Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAThe Fourth People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan 750021, ChinaJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USARTI International, Research Triangle Park, Durham, NC 27709, USARTI International, Research Triangle Park, Durham, NC 27709, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USACadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidney, and lungs. Toxic effects of Cd include hepatotoxicity, nephrotoxicity, pulmonary toxicity, and the development of various human cancers. Cd is also involved in the development and progression of fatty liver diseases and hepatocellular carcinoma. Cd affects liver function via modulation of cell survival/proliferation, differentiation, and apoptosis. Moreover, Cd dysregulates hepatic autophagy, an endogenous catabolic process that detoxifies damaged cell organelles or dysfunctional cytosolic proteins through vacuole-mediated sequestration and lysosomal degradation. In this article, we review recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level.http://dx.doi.org/10.1155/2021/9564297 |
| spellingShingle | Suryakant Niture Minghui Lin Qi Qi John T. Moore Keith E. Levine Reshan A. Fernando Deepak Kumar Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases Journal of Toxicology |
| title | Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases |
| title_full | Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases |
| title_fullStr | Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases |
| title_full_unstemmed | Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases |
| title_short | Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases |
| title_sort | role of autophagy in cadmium induced hepatotoxicity and liver diseases |
| url | http://dx.doi.org/10.1155/2021/9564297 |
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