TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer

TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer

IntroductionPatients with oral cancer often experience intense functional pain due to mechanical stimulation at the cancer site. The role of mechanosensitive ion channels in oral cancer pain, such as TRPV4, is not fully understood.ObjectivesOur objective was to investigate the role of Schwann cell T...

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Bibliographic Details
Main Authors: Yatendra Mulpuri, Nguyen H. Tu, Kenji Inoue, Grace Harden, Samuel J. Nicholson, Anisa Seenauth, Yan Huang, Keylin G. Escobar, Yalda Moayedi, Nigel W. Bunnett, Donna G. Albertson, Brian L. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pain Research
Subjects:
oral cancer
pain
TRPV4
Schwann cells
mechanical hypersensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2025.1532885/full
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