Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats
Three iron complexes were synthesized through green and sustainable procedures via chelation with salicylic acid, 3-methyl-1-phenyl-pyrazol-5-one, and ethylacetoactate under solvent-free conditions at room temperature. The synthesis assured the concept of both the twelve principles of Green Chemist...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2024-12-01
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| Series: | Acta Scientiarum: Biological Sciences |
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| Online Access: | https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/71230 |
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| author | Fayze Mohamed Eissa Heba Abdelaziz Abdelsalam Arfein Zeinab Mohamed |
| author_facet | Fayze Mohamed Eissa Heba Abdelaziz Abdelsalam Arfein Zeinab Mohamed |
| author_sort | Fayze Mohamed Eissa |
| collection | DOAJ |
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Three iron complexes were synthesized through green and sustainable procedures via chelation with salicylic acid, 3-methyl-1-phenyl-pyrazol-5-one, and ethylacetoactate under solvent-free conditions at room temperature. The synthesis assured the concept of both the twelve principles of Green Chemistry and Sustainability Commands. 48 male Wistar albino rats were administered gentamicin (GM) at a dose of 80 mg kg-1 day-1, with or without (I-SA), (I-MPP), (I-EAA) (120 mg kg-1 day-1) to evaluate the complexes' potential protective effects against GM-induced hepatotoxicity and nephrotoxicity. Oxidative stress markers and DNA fragmentation increased significantly, while the activity of the antioxidant enzymes SOD and CAT notably decreased. The study findings suggest that the three complexes serve as novel natural antioxidants, mitigating oxygen free radicals, lipid peroxidation, and DNA damage in gentamicin-treated rats. These compounds hold promise as potential natural drugs in future applications.
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| format | Article |
| id | doaj-art-dc1c8186bfca48cfa0f9cc071a1d2928 |
| institution | Kabale University |
| issn | 1679-9283 1807-863X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Biological Sciences |
| spelling | doaj-art-dc1c8186bfca48cfa0f9cc071a1d29282024-12-13T18:54:54ZengUniversidade Estadual de MaringáActa Scientiarum: Biological Sciences1679-92831807-863X2024-12-0146110.4025/actascibiolsci.v46i1.71230Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in ratsFayze Mohamed Eissa0Heba Abdelaziz1Abdelsalam Arfein2Zeinab Mohamed3Aswan UniversityAswan UniversityAswan UniversityAswan University Three iron complexes were synthesized through green and sustainable procedures via chelation with salicylic acid, 3-methyl-1-phenyl-pyrazol-5-one, and ethylacetoactate under solvent-free conditions at room temperature. The synthesis assured the concept of both the twelve principles of Green Chemistry and Sustainability Commands. 48 male Wistar albino rats were administered gentamicin (GM) at a dose of 80 mg kg-1 day-1, with or without (I-SA), (I-MPP), (I-EAA) (120 mg kg-1 day-1) to evaluate the complexes' potential protective effects against GM-induced hepatotoxicity and nephrotoxicity. Oxidative stress markers and DNA fragmentation increased significantly, while the activity of the antioxidant enzymes SOD and CAT notably decreased. The study findings suggest that the three complexes serve as novel natural antioxidants, mitigating oxygen free radicals, lipid peroxidation, and DNA damage in gentamicin-treated rats. These compounds hold promise as potential natural drugs in future applications. https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/71230green synthesis; sustainability; antioxidants markers; DNA damage; iron complexes |
| spellingShingle | Fayze Mohamed Eissa Heba Abdelaziz Abdelsalam Arfein Zeinab Mohamed Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats Acta Scientiarum: Biological Sciences green synthesis; sustainability; antioxidants markers; DNA damage; iron complexes |
| title | Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats |
| title_full | Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats |
| title_fullStr | Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats |
| title_full_unstemmed | Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats |
| title_short | Iron complexes: green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of DNA damage in rats |
| title_sort | iron complexes green and sustainable synthesis and evaluation of their potency as antioxidants and inhibitors of dna damage in rats |
| topic | green synthesis; sustainability; antioxidants markers; DNA damage; iron complexes |
| url | https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/71230 |
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