In vivo trafficking of cancer-derived exosomes and their role in metastasis
Cancer metastasis is one of the leading causes of cancer-related mortality. This process is driven by a combination of biological processes including invasion, intravasation, circulation, extravasation, and colonization of distant organs, among which cancer cell-derived exosomes facilitate metastasi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041724000301 |
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| author | Shih-Yen Wei Sarah E. Shelton Ying-Chieh Chen Ke Huang |
| author_facet | Shih-Yen Wei Sarah E. Shelton Ying-Chieh Chen Ke Huang |
| author_sort | Shih-Yen Wei |
| collection | DOAJ |
| description | Cancer metastasis is one of the leading causes of cancer-related mortality. This process is driven by a combination of biological processes including invasion, intravasation, circulation, extravasation, and colonization of distant organs, among which cancer cell-derived exosomes facilitate metastasis through their enriched oncogenic miRNAs and lncRNAs to enhance cancer cell migration and invasion, promote epithelial-mesenchymal transition in recipient cells, help cancer cells evade immune detection, and alter the microenvironment to promote the formation of a pre-metastatic niche. While the role of cancer exosomes in various metastatic processes has been extensively studied, the exosomal trafficking of cancer cell-derived exosomes has not been thoroughly reviewed. This review describes the dynamics between cancer cell-derived exosomes and various cellular components in blood and lymph circulation during cancer metastasis. Additionally, we emphasize the role of cancer exosomes in establishing pre-metastatic niches and in promoting metastasis to secondary sites. By offering a thorough review of exosome trafficking in cancer metastasis, this review may potentially help the future identification of treatment targets for metastasis inhibition. |
| format | Article |
| id | doaj-art-dc1baaae1dca4c14ae6651ecbaf70649 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-dc1baaae1dca4c14ae6651ecbaf706492025-01-19T06:27:00ZengElsevierExtracellular Vesicle2773-04172025-06-015100063In vivo trafficking of cancer-derived exosomes and their role in metastasisShih-Yen Wei0Sarah E. Shelton1Ying-Chieh Chen2Ke Huang3Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, Taiwan; Department of Cardiac Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USAJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill & North Carolina State University, Raleigh, NC, USADepartment of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, TaiwanDepartment of Biomedical Engineering, Columbia University, New York, USA; Corresponding author.Cancer metastasis is one of the leading causes of cancer-related mortality. This process is driven by a combination of biological processes including invasion, intravasation, circulation, extravasation, and colonization of distant organs, among which cancer cell-derived exosomes facilitate metastasis through their enriched oncogenic miRNAs and lncRNAs to enhance cancer cell migration and invasion, promote epithelial-mesenchymal transition in recipient cells, help cancer cells evade immune detection, and alter the microenvironment to promote the formation of a pre-metastatic niche. While the role of cancer exosomes in various metastatic processes has been extensively studied, the exosomal trafficking of cancer cell-derived exosomes has not been thoroughly reviewed. This review describes the dynamics between cancer cell-derived exosomes and various cellular components in blood and lymph circulation during cancer metastasis. Additionally, we emphasize the role of cancer exosomes in establishing pre-metastatic niches and in promoting metastasis to secondary sites. By offering a thorough review of exosome trafficking in cancer metastasis, this review may potentially help the future identification of treatment targets for metastasis inhibition.http://www.sciencedirect.com/science/article/pii/S2773041724000301Cancer exosomeMetastasisPre-metastasis niche |
| spellingShingle | Shih-Yen Wei Sarah E. Shelton Ying-Chieh Chen Ke Huang In vivo trafficking of cancer-derived exosomes and their role in metastasis Extracellular Vesicle Cancer exosome Metastasis Pre-metastasis niche |
| title | In vivo trafficking of cancer-derived exosomes and their role in metastasis |
| title_full | In vivo trafficking of cancer-derived exosomes and their role in metastasis |
| title_fullStr | In vivo trafficking of cancer-derived exosomes and their role in metastasis |
| title_full_unstemmed | In vivo trafficking of cancer-derived exosomes and their role in metastasis |
| title_short | In vivo trafficking of cancer-derived exosomes and their role in metastasis |
| title_sort | in vivo trafficking of cancer derived exosomes and their role in metastasis |
| topic | Cancer exosome Metastasis Pre-metastasis niche |
| url | http://www.sciencedirect.com/science/article/pii/S2773041724000301 |
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