From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis

From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis

Abstract Background Growing evidence suggests that gut microbiota (GM) plays a role in diabetic retinopathy (DR), but the causal microbial drivers and their stage-dependent roles during DR progression remain poorly characterised. Using genetic causality methods, we aim to depict a longitudinal GM ma...

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Bibliographic Details
Main Authors: Yifan Zhou, Jialong Dong, Zhenyu Wang, Chen Huang, Xiaotong Yu, Xinjun Wang, Bo Yang, Yuechen Wu, Qing Peng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Gut-eye axis
Circulating metabolites
Mendelian randomization study
Mediation analysis
Genome-wide association studies (GWAS)
Online Access:https://doi.org/10.1186/s13098-025-01813-6
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