Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation

Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation

BackgroundHypothyroidism is a frequent endocrine health issue that is linked to adverse cardiovascular events. Accumulating evidence suggests that thyroid hormone replacement does not fully reverse the cardiovascular complications associated with the disease despite normalization of serum thyroid ho...

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Bibliographic Details
Main Authors: Asmaa M. Gaber, Adel Abdel-Moneim, Eman S. Abdel-Reheim, Gamal Allam, Manal Abdul-Hamid, Ahmed Hosni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
hypothyroidism
cardiac dysfunction
hesperidin
miRNAs
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1553992/full
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