Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review
Background: Angiosarcomas are highly aggressive malignancies with endothelial differentiation, presenting considerable challenges in oncology, especially when arising in rare locations such as the spleen. These tumors predominantly affect adults and are commonly found in the skin, breast, liver, or...
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MDPI AG
2024-10-01
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| author | Jakub Misiak Bernard Sokołowski Norbert Skrobisz Mateusz Matczak Marcin Braun |
| author_facet | Jakub Misiak Bernard Sokołowski Norbert Skrobisz Mateusz Matczak Marcin Braun |
| author_sort | Jakub Misiak |
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| description | Background: Angiosarcomas are highly aggressive malignancies with endothelial differentiation, presenting considerable challenges in oncology, especially when arising in rare locations such as the spleen. These tumors predominantly affect adults and are commonly found in the skin, breast, liver, or soft tissues, with more unusual occurrences in other organs. Angiosarcomas have a high propensity for metastasis, typically spreading to the liver, lungs, lymph nodes, and gastrointestinal tract. Splenic angiosarcoma, with fewer than 300 documented cases, is an especially rare and complex form of this malignancy. Case presentation: This report details a case of splenic angiosarcoma in a 45-year-old male, where bone marrow metastases were the first clinical presentation, initially mimicking myelodysplastic syndrome (MDS) due to persistent pancytopenia. Conclusions: The eventual identification of the splenic origin underscores the diagnostic difficulties and clinical challenges inherent in managing such atypical and rare presentations. |
| format | Article |
| id | doaj-art-dc0c369a5eca4bc1a3811c46f79158a9 |
| institution | Kabale University |
| issn | 2038-8330 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj-art-dc0c369a5eca4bc1a3811c46f79158a92024-12-27T14:28:41ZengMDPI AGHematology Reports2038-83302024-10-0116464865510.3390/hematolrep16040063Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature ReviewJakub Misiak0Bernard Sokołowski1Norbert Skrobisz2Mateusz Matczak3Marcin Braun4Department of Pathology, Chair of Oncology, Medical University of Lodz, 92-213 Lodz, PolandDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 92-213 Lodz, PolandDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 92-213 Lodz, PolandDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 92-213 Lodz, PolandDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 92-213 Lodz, PolandBackground: Angiosarcomas are highly aggressive malignancies with endothelial differentiation, presenting considerable challenges in oncology, especially when arising in rare locations such as the spleen. These tumors predominantly affect adults and are commonly found in the skin, breast, liver, or soft tissues, with more unusual occurrences in other organs. Angiosarcomas have a high propensity for metastasis, typically spreading to the liver, lungs, lymph nodes, and gastrointestinal tract. Splenic angiosarcoma, with fewer than 300 documented cases, is an especially rare and complex form of this malignancy. Case presentation: This report details a case of splenic angiosarcoma in a 45-year-old male, where bone marrow metastases were the first clinical presentation, initially mimicking myelodysplastic syndrome (MDS) due to persistent pancytopenia. Conclusions: The eventual identification of the splenic origin underscores the diagnostic difficulties and clinical challenges inherent in managing such atypical and rare presentations.https://www.mdpi.com/2038-8330/16/4/63splenic angiosarcomabone marrow metastasespancytopeniamyelodysplastic syndrome |
| spellingShingle | Jakub Misiak Bernard Sokołowski Norbert Skrobisz Mateusz Matczak Marcin Braun Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review Hematology Reports splenic angiosarcoma bone marrow metastases pancytopenia myelodysplastic syndrome |
| title | Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review |
| title_full | Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review |
| title_fullStr | Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review |
| title_full_unstemmed | Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review |
| title_short | Pancytopenia Related to Splenic Angiosarcoma: A Case Report and Literature Review |
| title_sort | pancytopenia related to splenic angiosarcoma a case report and literature review |
| topic | splenic angiosarcoma bone marrow metastases pancytopenia myelodysplastic syndrome |
| url | https://www.mdpi.com/2038-8330/16/4/63 |
| work_keys_str_mv | AT jakubmisiak pancytopeniarelatedtosplenicangiosarcomaacasereportandliteraturereview AT bernardsokołowski pancytopeniarelatedtosplenicangiosarcomaacasereportandliteraturereview AT norbertskrobisz pancytopeniarelatedtosplenicangiosarcomaacasereportandliteraturereview AT mateuszmatczak pancytopeniarelatedtosplenicangiosarcomaacasereportandliteraturereview AT marcinbraun pancytopeniarelatedtosplenicangiosarcomaacasereportandliteraturereview |