Programmed evolution for optimization of orthogonal metabolic output in bacteria.

Programmed evolution for optimization of orthogonal metabolic output in bacteria.

Current use of microbes for metabolic engineering suffers from loss of metabolic output due to natural selection. Rather than combat the evolution of bacterial populations, we chose to embrace what makes biological engineering unique among engineering fields - evolving materials. We harnessed bacter...

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Main Authors: Todd T Eckdahl, A Malcolm Campbell, Laurie J Heyer, Jeffrey L Poet, David N Blauch, Nicole L Snyder, Dustin T Atchley, Erich J Baker, Micah Brown, Elizabeth C Brunner, Sean A Callen, Jesse S Campbell, Caleb J Carr, David R Carr, Spencer A Chadinha, Grace I Chester, Josh Chester, Ben R Clarkson, Kelly E Cochran, Shannon E Doherty, Catherine Doyle, Sarah Dwyer, Linnea M Edlin, Rebecca A Evans, Taylor Fluharty, Janna Frederick, Jonah Galeota-Sprung, Betsy L Gammon, Brandon Grieshaber, Jessica Gronniger, Katelyn Gutteridge, Joel Henningsen, Bradley Isom, Hannah L Itell, Erica C Keffeler, Andrew J Lantz, Jonathan N Lim, Erin P McGuire, Alexander K Moore, Jerrad Morton, Meredith Nakano, Sara A Pearson, Virginia Perkins, Phoebe Parrish, Claire E Pierson, Sachith Polpityaarachchige, Michael J Quaney, Abagael Slattery, Kathryn E Smith, Jackson Spell, Morgan Spencer, Telavive Taye, Kamay Trueblood, Caroline J Vrana, E Tucker Whitesides
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118322&type=printable
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