Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients
Introduction: In the context of cardiology and neurology, special attention is paid to the problems of cardiovascular and cerebrovascular pathologies, often caused by vascular dysfunction. Haemodynamic parameters, in particular arterial stiffness (AS), and epicardial fat thickness (EFT), play a sign...
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| Language: | English |
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Belgorod National Research University
2024-12-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/518 |
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| author | Nadezhda N. Pribylova Kristina O. Leonidova Vladislav S. Pribylov Evgeny A. Shabanov Sergey A. Pribylov Nikita V. Novikov |
| author_facet | Nadezhda N. Pribylova Kristina O. Leonidova Vladislav S. Pribylov Evgeny A. Shabanov Sergey A. Pribylov Nikita V. Novikov |
| author_sort | Nadezhda N. Pribylova |
| collection | DOAJ |
| description | Introduction: In the context of cardiology and neurology, special attention is paid to the problems of cardiovascular and cerebrovascular pathologies, often caused by vascular dysfunction. Haemodynamic parameters, in particular arterial stiffness (AS), and epicardial fat thickness (EFT), play a significant role in the assessment of cardiovascular health. The aim of the study was to evaluate the correlation between arterial stiffness, pulmonary hypertension (PH), epicardial fat thickness and diastolic myocardial dysfunction in comorbid patients.
Materials and Methods: The comparative study was conducted in three groups of patients with the most frequent comorbid pathology. The first group (n=75) included patients with ischaemic heart disease (IHD), arterial hypertension stage II-III and chronic obstructive pulmonary disease (COPD) stage II-III. The second group (n=50) consisted of patients with IHD and arterial hypertension without COPD. The third group (n=33) included patients with IHD without comorbidities.
Results: The study revealed a significant correlation between indices of AS, blood pressure (BP), EFT and PH in patients with comorbid conditions. The study found that the addition of the combined antihypertensive drug amlodipine-perindopril to standard therapy contributed to normalization of AS, PH and BP during three months of treatment. There was also a significant improvement in the patients’ quality of life, reduction of dyspnoea and heart failure symptoms.
Conclusion: The obtained data confirm the presence of correlation between AS, BP, PH and EFT in patients with IHD, AH and COPD, which may serve as indicators of comorbid diseases. The use of combined antihypertensive drug amlodipine-perindopril seems reasonable and scientifically justified, especially after coronary stenting. |
| format | Article |
| id | doaj-art-dc0669d035a24294ae6bf2c9bebf9f26 |
| institution | Kabale University |
| issn | 2658-381X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj-art-dc0669d035a24294ae6bf2c9bebf9f262025-01-08T13:16:12ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2024-12-011049910510.18413/rrpharmacology.10.518Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patientsNadezhda N. Pribylova0https://orcid.org/0000-0001-6788-518XKristina O. Leonidova1https://orcid.org/0000-0001-6120-6748Vladislav S. Pribylov2https://orcid.org/0000-0002-4545-9339Evgeny A. Shabanov3https://orcid.org/0000-0002-5790-4196Sergey A. Pribylov4https://orcid.org/0000-0002-2913-493XNikita V. Novikov5https://orcid.org/0009-0001-3666-9465Kursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityIntroduction: In the context of cardiology and neurology, special attention is paid to the problems of cardiovascular and cerebrovascular pathologies, often caused by vascular dysfunction. Haemodynamic parameters, in particular arterial stiffness (AS), and epicardial fat thickness (EFT), play a significant role in the assessment of cardiovascular health. The aim of the study was to evaluate the correlation between arterial stiffness, pulmonary hypertension (PH), epicardial fat thickness and diastolic myocardial dysfunction in comorbid patients. Materials and Methods: The comparative study was conducted in three groups of patients with the most frequent comorbid pathology. The first group (n=75) included patients with ischaemic heart disease (IHD), arterial hypertension stage II-III and chronic obstructive pulmonary disease (COPD) stage II-III. The second group (n=50) consisted of patients with IHD and arterial hypertension without COPD. The third group (n=33) included patients with IHD without comorbidities. Results: The study revealed a significant correlation between indices of AS, blood pressure (BP), EFT and PH in patients with comorbid conditions. The study found that the addition of the combined antihypertensive drug amlodipine-perindopril to standard therapy contributed to normalization of AS, PH and BP during three months of treatment. There was also a significant improvement in the patients’ quality of life, reduction of dyspnoea and heart failure symptoms. Conclusion: The obtained data confirm the presence of correlation between AS, BP, PH and EFT in patients with IHD, AH and COPD, which may serve as indicators of comorbid diseases. The use of combined antihypertensive drug amlodipine-perindopril seems reasonable and scientifically justified, especially after coronary stenting.https://rrpharmacology.ru/index.php/journal/article/view/518coronary heart diseasearterial hypertensionchronic obstructive pulmonary diseasearterial stiffnesspulmonary hypertensionepicardial fat thicknessamlodipine-perindoprilcoronary stenting |
| spellingShingle | Nadezhda N. Pribylova Kristina O. Leonidova Vladislav S. Pribylov Evgeny A. Shabanov Sergey A. Pribylov Nikita V. Novikov Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients Research Results in Pharmacology coronary heart disease arterial hypertension chronic obstructive pulmonary disease arterial stiffness pulmonary hypertension epicardial fat thickness amlodipine-perindopril coronary stenting |
| title | Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| title_full | Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| title_fullStr | Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| title_full_unstemmed | Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| title_short | Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| title_sort | diagnosis and treatment of arterial stiffness pulmonary hypertension diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients |
| topic | coronary heart disease arterial hypertension chronic obstructive pulmonary disease arterial stiffness pulmonary hypertension epicardial fat thickness amlodipine-perindopril coronary stenting |
| url | https://rrpharmacology.ru/index.php/journal/article/view/518 |
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