Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC)
Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease with significant functional impairment. Health Assessment Questionnaire-Disability Index (HAQ-DI) is a reliable and validated outcome measure for a variety of arthritides including PsA. Objective: The objective of this study...
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SAGE Publishing
2023-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=120;epage=125;aulast=Shobha |
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| author | Vineeta Shobha Chanakya Kodishala S Chandrashekara Sharath Kumar Vikram Haridas Vijay Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanad Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikramraj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivas J Ramya Benzeeta Pinto Beenish Nazir Harshini Mahendranath |
| author_facet | Vineeta Shobha Chanakya Kodishala S Chandrashekara Sharath Kumar Vikram Haridas Vijay Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanad Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikramraj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivas J Ramya Benzeeta Pinto Beenish Nazir Harshini Mahendranath |
| author_sort | Vineeta Shobha |
| collection | DOAJ |
| description | Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease with significant functional impairment. Health Assessment Questionnaire-Disability Index (HAQ-DI) is a reliable and validated outcome measure for a variety of arthritides including PsA.
Objective: The objective of this study was to assess the disability as an outcome measure in PsA using the Indian version of HAQ (I-HAQ).
Methods: The I-HAQ was administered to PsA patients diagnosed as per the Classification Criteria for PsA. The I-HAQ comprises 12 questions (nine basic and three advanced activities of daily living (ADLs), on the standard HAQ format) relevant to the Indian population.
Results: In the 549 participants, the mean I-HAQ was 0.31 (0.45) and 48.2% had mild-to-moderate disability (I-HAQ>0–1). Female gender, older age, higher skin, joint scores, and Disease Activity Index for PsA were associated with some disability (I-HAQ>0). Symmetric polyarthritis (0.34) and spondyloarthritis (0.32) had a significantly higher disability compared to other subsets. Analyzing the individual questions of I-HAQ, squatting in the toilet or sitting cross-legged on the floor (r = 0.78), walking 3 km (r = 0.77), and climbing a flight of stairs (r = 0.74) correlated maximally to the total I-HAQ. ADL which was affected most frequently was “climbing a flight of stairs.” I-HAQ was significantly lower in patients who had been on disease-modifying antirheumatic drugs for 6 months or more (P = 0.0001).
Conclusions: The Indian version of HAQ-DI could be efficiently employed to assess outcomes in our cohort. Nearly half of the cohort had mild-to-moderate disability suggesting a high burden of inflammation. Higher joint activity scores are strongly associated with disability. |
| format | Article |
| id | doaj-art-dbfce11f051c4c3284f1e9788df5863f |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
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| series | Indian Journal of Rheumatology |
| spelling | doaj-art-dbfce11f051c4c3284f1e9788df5863f2025-02-02T23:11:31ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012023-01-0118212012510.4103/injr.injr_285_21Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC)Vineeta ShobhaChanakya KodishalaS ChandrashekaraSharath KumarVikram HaridasVijay RaoRamesh JoisManisha DawareYogesh Preet SinghShweta SinghaiB G DharmanadPramod ChebbiR SubramanianAshwini KamathUma KarjiigiVikramraj K JainChethana DharmapalaiahShiva PrasadC SrinivasJ RamyaBenzeeta PintoBeenish NazirHarshiniMahendranathIntroduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease with significant functional impairment. Health Assessment Questionnaire-Disability Index (HAQ-DI) is a reliable and validated outcome measure for a variety of arthritides including PsA. Objective: The objective of this study was to assess the disability as an outcome measure in PsA using the Indian version of HAQ (I-HAQ). Methods: The I-HAQ was administered to PsA patients diagnosed as per the Classification Criteria for PsA. The I-HAQ comprises 12 questions (nine basic and three advanced activities of daily living (ADLs), on the standard HAQ format) relevant to the Indian population. Results: In the 549 participants, the mean I-HAQ was 0.31 (0.45) and 48.2% had mild-to-moderate disability (I-HAQ>0–1). Female gender, older age, higher skin, joint scores, and Disease Activity Index for PsA were associated with some disability (I-HAQ>0). Symmetric polyarthritis (0.34) and spondyloarthritis (0.32) had a significantly higher disability compared to other subsets. Analyzing the individual questions of I-HAQ, squatting in the toilet or sitting cross-legged on the floor (r = 0.78), walking 3 km (r = 0.77), and climbing a flight of stairs (r = 0.74) correlated maximally to the total I-HAQ. ADL which was affected most frequently was “climbing a flight of stairs.” I-HAQ was significantly lower in patients who had been on disease-modifying antirheumatic drugs for 6 months or more (P = 0.0001). Conclusions: The Indian version of HAQ-DI could be efficiently employed to assess outcomes in our cohort. Nearly half of the cohort had mild-to-moderate disability suggesting a high burden of inflammation. Higher joint activity scores are strongly associated with disability.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=120;epage=125;aulast=Shobhahealth assessment questionnaire-disability indexhealth assessment questionnaire-disability index indiapatient global assessmentpatient-reported outcomesphysician global assessmentvisual analog score |
| spellingShingle | Vineeta Shobha Chanakya Kodishala S Chandrashekara Sharath Kumar Vikram Haridas Vijay Rao Ramesh Jois Manisha Daware Yogesh Preet Singh Shweta Singhai B G Dharmanad Pramod Chebbi R Subramanian Ashwini Kamath Uma Karjiigi Vikramraj K Jain Chethana Dharmapalaiah Shiva Prasad C Srinivas J Ramya Benzeeta Pinto Beenish Nazir Harshini Mahendranath Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) Indian Journal of Rheumatology health assessment questionnaire-disability index health assessment questionnaire-disability index india patient global assessment patient-reported outcomes physician global assessment visual analog score |
| title | Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) |
| title_full | Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) |
| title_fullStr | Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) |
| title_full_unstemmed | Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) |
| title_short | Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) |
| title_sort | impaired mobility drives disability in psoriatic arthritis an observational study from karnataka psoriatic arthritis cohort kpsac |
| topic | health assessment questionnaire-disability index health assessment questionnaire-disability index india patient global assessment patient-reported outcomes physician global assessment visual analog score |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=120;epage=125;aulast=Shobha |
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