Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity
Mannose-capped lipoarabinomannan (ManLAM) is a high molecular mass amphipathic lipoglycan identified in pathogenic Mycobacterium tuberculosis (M. tb) and M. bovis Bacillus Calmette-Guérin (BCG). ManLAM, serves as both an immunogen and a modulator of the host immune system, and its critical role in m...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1649097 |
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| author | Kai-Liang Zhou Xin Li Xiao-Lian Zhang Qin Pan |
| author_facet | Kai-Liang Zhou Xin Li Xiao-Lian Zhang Qin Pan |
| author_sort | Kai-Liang Zhou |
| collection | DOAJ |
| description | Mannose-capped lipoarabinomannan (ManLAM) is a high molecular mass amphipathic lipoglycan identified in pathogenic Mycobacterium tuberculosis (M. tb) and M. bovis Bacillus Calmette-Guérin (BCG). ManLAM, serves as both an immunogen and a modulator of the host immune system, and its critical role in mycobacterial survival during infection has been well-characterized. ManLAM can be recognized by various types of receptors on both innate and adaptive immune cells, including macrophages, dendritic cells (DCs), neutrophils, natural killer T (NKT) cells, T cells and B cells. MamLAM has been shown to affect phagocytosis, cytokine production, antigen presentation, T cell activation and polarization, as well as antibody production. Exploring the mechanisms underlying the roles of ManLAM during mycobacterial infection will aid in improving tuberculosis (TB) prevention, diagnosis and treatment interventions. In this review, we highlight the interaction between ManLAM and receptors, intracellular signalling pathways triggered by ManLAM and its roles in both innate and adaptive immune responses. |
| format | Article |
| id | doaj-art-dbfbccfc8ea6412aab8b1881d4f4314a |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-dbfbccfc8ea6412aab8b1881d4f4314a2025-08-20T02:26:09ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811168117710.1080/22221751.2019.1649097Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunityKai-Liang Zhou0Xin Li1Xiao-Lian Zhang2Qin Pan3State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Medicine, Wuhan, People’s Republic of ChinaState Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Medicine, Wuhan, People’s Republic of ChinaState Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Medicine, Wuhan, People’s Republic of ChinaState Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Medicine, Wuhan, People’s Republic of ChinaMannose-capped lipoarabinomannan (ManLAM) is a high molecular mass amphipathic lipoglycan identified in pathogenic Mycobacterium tuberculosis (M. tb) and M. bovis Bacillus Calmette-Guérin (BCG). ManLAM, serves as both an immunogen and a modulator of the host immune system, and its critical role in mycobacterial survival during infection has been well-characterized. ManLAM can be recognized by various types of receptors on both innate and adaptive immune cells, including macrophages, dendritic cells (DCs), neutrophils, natural killer T (NKT) cells, T cells and B cells. MamLAM has been shown to affect phagocytosis, cytokine production, antigen presentation, T cell activation and polarization, as well as antibody production. Exploring the mechanisms underlying the roles of ManLAM during mycobacterial infection will aid in improving tuberculosis (TB) prevention, diagnosis and treatment interventions. In this review, we highlight the interaction between ManLAM and receptors, intracellular signalling pathways triggered by ManLAM and its roles in both innate and adaptive immune responses.https://www.tandfonline.com/doi/10.1080/22221751.2019.1649097M. tbManLAMinnate and adaptive immunityimmunomodulatorylipoglycaninfection |
| spellingShingle | Kai-Liang Zhou Xin Li Xiao-Lian Zhang Qin Pan Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity Emerging Microbes and Infections M. tb ManLAM innate and adaptive immunity immunomodulatory lipoglycan infection |
| title | Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity |
| title_full | Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity |
| title_fullStr | Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity |
| title_full_unstemmed | Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity |
| title_short | Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity |
| title_sort | mycobacterial mannose capped lipoarabinomannan a modulator bridging innate and adaptive immunity |
| topic | M. tb ManLAM innate and adaptive immunity immunomodulatory lipoglycan infection |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1649097 |
| work_keys_str_mv | AT kailiangzhou mycobacterialmannosecappedlipoarabinomannanamodulatorbridginginnateandadaptiveimmunity AT xinli mycobacterialmannosecappedlipoarabinomannanamodulatorbridginginnateandadaptiveimmunity AT xiaolianzhang mycobacterialmannosecappedlipoarabinomannanamodulatorbridginginnateandadaptiveimmunity AT qinpan mycobacterialmannosecappedlipoarabinomannanamodulatorbridginginnateandadaptiveimmunity |