Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response

Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response

IntroductionTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. A crucial factor in Mtb's virulence is the ESX-5 secretion system, which transports PE/PPE proteins such as PE18 and PPE26. These proteins modulate host-pathogen interactio...

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Bibliographic Details
Main Authors: Aquib Ehtram, Mohd Shariq, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
macrophage activation marker
phagosome
host-pathogen interaction
Th1 immune response
immune modulation
proinflammatory cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517822/full
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