Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation
Ischemia-reperfusion (I-R) injury after liver transplantation (LT) induces intra- and/or extrahepatic nonanastomotic ischemic-type biliary lesions (ITBLs). Subsequent bile duct stricture is a significant cause of morbidity and even mortality in patients who underwent LT. Although the pathogenesis of...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/164329 |
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| author | Raffaele Cursio Jean Gugenheim |
| author_facet | Raffaele Cursio Jean Gugenheim |
| author_sort | Raffaele Cursio |
| collection | DOAJ |
| description | Ischemia-reperfusion (I-R) injury after liver transplantation (LT) induces intra- and/or extrahepatic nonanastomotic ischemic-type biliary lesions (ITBLs). Subsequent bile duct stricture is a significant cause of morbidity and even mortality in patients who underwent LT. Although the pathogenesis of ITBLs is multifactorial, there are three main interconnected mechanisms responsible for their formation: cold and warm I-R injury, injury induced by cytotoxic bile salts, and immunological-mediated injury. Cold and warm ischemic insult can induce direct injury to the cholangiocytes and/or damage to the arterioles of the peribiliary vascular plexus, which in turn leads to apoptosis and necrosis of the cholangiocytes. Liver grafts from suboptimal or extended-criteria donors are more susceptible to cold and warm I-R injury and develop more easily ITBLs than normal livers. This paper, focusing on liver I-R injury, reviews the risk factors and mechanisms leading to ITBLs following LT. |
| format | Article |
| id | doaj-art-dbfa16e3f7ef4eda9b6ce52fc83f114a |
| institution | DOAJ |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-dbfa16e3f7ef4eda9b6ce52fc83f114a2025-08-20T03:23:57ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/164329164329Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver TransplantationRaffaele Cursio0Jean Gugenheim1Service de Chirurgie et Transplantation Hépatique, Hôpital l'Archet 2, Centre Hospitalier Universitaire de Nice, Université de Nice Sophia-Antipolis, 151 Route Saint Antoine de Ginestière, B.P. 3079, 06202 Nice Cedex 2, FranceService de Chirurgie et Transplantation Hépatique, Hôpital l'Archet 2, Centre Hospitalier Universitaire de Nice, Université de Nice Sophia-Antipolis, 151 Route Saint Antoine de Ginestière, B.P. 3079, 06202 Nice Cedex 2, FranceIschemia-reperfusion (I-R) injury after liver transplantation (LT) induces intra- and/or extrahepatic nonanastomotic ischemic-type biliary lesions (ITBLs). Subsequent bile duct stricture is a significant cause of morbidity and even mortality in patients who underwent LT. Although the pathogenesis of ITBLs is multifactorial, there are three main interconnected mechanisms responsible for their formation: cold and warm I-R injury, injury induced by cytotoxic bile salts, and immunological-mediated injury. Cold and warm ischemic insult can induce direct injury to the cholangiocytes and/or damage to the arterioles of the peribiliary vascular plexus, which in turn leads to apoptosis and necrosis of the cholangiocytes. Liver grafts from suboptimal or extended-criteria donors are more susceptible to cold and warm I-R injury and develop more easily ITBLs than normal livers. This paper, focusing on liver I-R injury, reviews the risk factors and mechanisms leading to ITBLs following LT.http://dx.doi.org/10.1155/2012/164329 |
| spellingShingle | Raffaele Cursio Jean Gugenheim Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation Journal of Transplantation |
| title | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation |
| title_full | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation |
| title_fullStr | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation |
| title_full_unstemmed | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation |
| title_short | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation |
| title_sort | ischemia reperfusion injury and ischemic type biliary lesions following liver transplantation |
| url | http://dx.doi.org/10.1155/2012/164329 |
| work_keys_str_mv | AT raffaelecursio ischemiareperfusioninjuryandischemictypebiliarylesionsfollowinglivertransplantation AT jeangugenheim ischemiareperfusioninjuryandischemictypebiliarylesionsfollowinglivertransplantation |