Maic Audo Lin Sihombing
Diabetes mellitus is one of the common metabolic disorders with increasing prevalence during recent years with hyperglycemia as its characteristic. DM has been shown to be a state of free radicals over production resulted from hyperglycemia that can activate cellular signaling pathways transcription...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2015-06-01
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| Series: | Journal of Experimental Life Science |
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| Online Access: | https://jels.ub.ac.id/index.php/jels/article/view/161 |
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| author | Maic Audo Lin Sihombing Sutiman B. Sumitro Muhaimin Rifa'i |
| author_facet | Maic Audo Lin Sihombing Sutiman B. Sumitro Muhaimin Rifa'i |
| author_sort | Maic Audo Lin Sihombing |
| collection | DOAJ |
| description | Diabetes mellitus is one of the common metabolic disorders with increasing prevalence during recent years with hyperglycemia as its characteristic. DM has been shown to be a state of free radicals over production resulted from hyperglycemia that can activate cellular signaling pathways transcription of factor NF-κB which stimulates the production of several inflammatory mediators andl lead to chronic inflammation. Chronic inflammation is implicated in β-cell damage and function and promotes apoptosis. EMSA Eritin is a polyherbal consisting of soy bean extracts, coconut water extract and red rice extract that assumed to be antidiabetic and anti-inflammatory. This study will assess the effectiveness of EMSA Eritin against inflammation in diabetes mellitus by measuring levels of NF-κB produced by immunocompetent cells in DM mice model. Streptozotocin 100 mg.kg-1 BW is used to induce diabetes mellitus in mice. Oral administration of EMSA Eritin was given for 14 days with dose of 0.3125 mg.g-1 BW, 3.125 mg.g-1 BW and 31.25 mg.g-1 BW. Data were analyzed using One-way ANOVA (p<0.05) and Duncan test using SPSS 16.0 for Windows. The results showed that EMSA Eritin can be used as an alternative therapy for the treatment of DM. The level of NF-κB in diabetic mice significantly decreased when the mice received EMSA Eritin. |
| format | Article |
| id | doaj-art-dbf4d6c504fd495b918e6a52b644652b |
| institution | OA Journals |
| issn | 2087-2852 2338-1655 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Experimental Life Science |
| spelling | doaj-art-dbf4d6c504fd495b918e6a52b644652b2025-08-20T01:55:33ZengUniversity of BrawijayaJournal of Experimental Life Science2087-28522338-16552015-06-01512430https://doi.org/10.21776/ub.jels.2015.005.01.05Maic Audo Lin SihombingMaic Audo Lin Sihombing0Sutiman B. Sumitro1Muhaimin Rifa'i2Universitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaDiabetes mellitus is one of the common metabolic disorders with increasing prevalence during recent years with hyperglycemia as its characteristic. DM has been shown to be a state of free radicals over production resulted from hyperglycemia that can activate cellular signaling pathways transcription of factor NF-κB which stimulates the production of several inflammatory mediators andl lead to chronic inflammation. Chronic inflammation is implicated in β-cell damage and function and promotes apoptosis. EMSA Eritin is a polyherbal consisting of soy bean extracts, coconut water extract and red rice extract that assumed to be antidiabetic and anti-inflammatory. This study will assess the effectiveness of EMSA Eritin against inflammation in diabetes mellitus by measuring levels of NF-κB produced by immunocompetent cells in DM mice model. Streptozotocin 100 mg.kg-1 BW is used to induce diabetes mellitus in mice. Oral administration of EMSA Eritin was given for 14 days with dose of 0.3125 mg.g-1 BW, 3.125 mg.g-1 BW and 31.25 mg.g-1 BW. Data were analyzed using One-way ANOVA (p<0.05) and Duncan test using SPSS 16.0 for Windows. The results showed that EMSA Eritin can be used as an alternative therapy for the treatment of DM. The level of NF-κB in diabetic mice significantly decreased when the mice received EMSA Eritin.https://jels.ub.ac.id/index.php/jels/article/view/161diabetes mellitusemsa eritinnf-κbros |
| spellingShingle | Maic Audo Lin Sihombing Sutiman B. Sumitro Muhaimin Rifa'i Maic Audo Lin Sihombing Journal of Experimental Life Science diabetes mellitus emsa eritin nf-κb ros |
| title | Maic Audo Lin Sihombing |
| title_full | Maic Audo Lin Sihombing |
| title_fullStr | Maic Audo Lin Sihombing |
| title_full_unstemmed | Maic Audo Lin Sihombing |
| title_short | Maic Audo Lin Sihombing |
| title_sort | maic audo lin sihombing |
| topic | diabetes mellitus emsa eritin nf-κb ros |
| url | https://jels.ub.ac.id/index.php/jels/article/view/161 |
| work_keys_str_mv | AT maicaudolinsihombing maicaudolinsihombing AT sutimanbsumitro maicaudolinsihombing AT muhaiminrifai maicaudolinsihombing |