A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation
Schizophrenia (SZ) and bipolar disorder (BD) are characterized by social impairments. Social impairment also occurs in the general community. Across clinical and nonclinical groups social impairment may be related to deficits in social approach and/or social avoidance motivation. However, the neural...
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Elsevier
2025-09-01
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| Series: | Schizophrenia Research: Cognition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215001325000253 |
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| author | Amy M. Jimenez Samuel J. Abplanalp Naomi I. Eisenberger William P. Horan Junghee Lee Amanda McCleery Ana Ceci Myers David J. Miklowitz Eric A. Reavis L. Felice Reddy Jonathan K. Wynn Michael F. Green |
| author_facet | Amy M. Jimenez Samuel J. Abplanalp Naomi I. Eisenberger William P. Horan Junghee Lee Amanda McCleery Ana Ceci Myers David J. Miklowitz Eric A. Reavis L. Felice Reddy Jonathan K. Wynn Michael F. Green |
| author_sort | Amy M. Jimenez |
| collection | DOAJ |
| description | Schizophrenia (SZ) and bipolar disorder (BD) are characterized by social impairments. Social impairment also occurs in the general community. Across clinical and nonclinical groups social impairment may be related to deficits in social approach and/or social avoidance motivation. However, the neural basis of social motivation deficits in SZ and BD is not well understood, nor is it known if they reflect features of the illness or are secondary to other factors such as social isolation. To fill these knowledge gaps, 31 individuals with SZ, 27 with BD, and 42 community comparisons (CCs) completed a team-based task during fMRI in which positive and negative feedback was provided by pictures of teammates or opponents. Importantly, the CC group was enriched for self-reported social isolation. fMRI analyses in five key regions of interest (ROIs; ventral striatum, orbital frontal cortex, insula, dorsal anterior cingulate cortex, amygdala), secondary whole-brain analyses, and associations between ROI activity and social approach/avoidance motivation were performed. Across groups, ventral striatum and amygdala showed greater activation to positive versus negative feedback. In SZ, ventral striatum activity to positive feedback was correlated with social approach motivation. In CCs, amygdala activity during negative feedback was correlated with social avoidance motivation. Whole-brain analyses revealed greater activation in BD compared to SZ and CCs in fronto-parietal regions when feedback was provided by an opponent. Findings support disturbed reward sensitivity as a core component of poor social approach motivation in SZ and offer avenues for future research into neural mechanisms underlying social impairment in BD and the general community. |
| format | Article |
| id | doaj-art-dbf441701fd14643b637709b8a15ed7f |
| institution | OA Journals |
| issn | 2215-0013 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Schizophrenia Research: Cognition |
| spelling | doaj-art-dbf441701fd14643b637709b8a15ed7f2025-08-20T02:05:49ZengElsevierSchizophrenia Research: Cognition2215-00132025-09-014110036710.1016/j.scog.2025.100367A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivationAmy M. Jimenez0Samuel J. Abplanalp1Naomi I. Eisenberger2William P. Horan3Junghee Lee4Amanda McCleery5Ana Ceci Myers6David J. Miklowitz7Eric A. Reavis8L. Felice Reddy9Jonathan K. Wynn10Michael F. Green11VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; Corresponding author at: VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USADepartment of Psychology, UCLA, 502 Portola Plaza, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; Bristol-Myers Squibb Company, Route 206 & Province Line Rd, Princeton, NJ 08543, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Ave S, Birmingham, AL 35233, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; Department of Psychological and Brain Sciences, University of Iowa, 340 Iowa Ave, Iowa City, IA 52242, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; Department of Psychiatry, University of North Carolina, 333 S. Columbia St, MacNider Hall Chapel Hill, NC 27514, USAVA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA; VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USASchizophrenia (SZ) and bipolar disorder (BD) are characterized by social impairments. Social impairment also occurs in the general community. Across clinical and nonclinical groups social impairment may be related to deficits in social approach and/or social avoidance motivation. However, the neural basis of social motivation deficits in SZ and BD is not well understood, nor is it known if they reflect features of the illness or are secondary to other factors such as social isolation. To fill these knowledge gaps, 31 individuals with SZ, 27 with BD, and 42 community comparisons (CCs) completed a team-based task during fMRI in which positive and negative feedback was provided by pictures of teammates or opponents. Importantly, the CC group was enriched for self-reported social isolation. fMRI analyses in five key regions of interest (ROIs; ventral striatum, orbital frontal cortex, insula, dorsal anterior cingulate cortex, amygdala), secondary whole-brain analyses, and associations between ROI activity and social approach/avoidance motivation were performed. Across groups, ventral striatum and amygdala showed greater activation to positive versus negative feedback. In SZ, ventral striatum activity to positive feedback was correlated with social approach motivation. In CCs, amygdala activity during negative feedback was correlated with social avoidance motivation. Whole-brain analyses revealed greater activation in BD compared to SZ and CCs in fronto-parietal regions when feedback was provided by an opponent. Findings support disturbed reward sensitivity as a core component of poor social approach motivation in SZ and offer avenues for future research into neural mechanisms underlying social impairment in BD and the general community.http://www.sciencedirect.com/science/article/pii/S2215001325000253SchizophreniaBipolar disorderSocial motivationRewardApproach/avoidanceSocial anhedonia |
| spellingShingle | Amy M. Jimenez Samuel J. Abplanalp Naomi I. Eisenberger William P. Horan Junghee Lee Amanda McCleery Ana Ceci Myers David J. Miklowitz Eric A. Reavis L. Felice Reddy Jonathan K. Wynn Michael F. Green A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation Schizophrenia Research: Cognition Schizophrenia Bipolar disorder Social motivation Reward Approach/avoidance Social anhedonia |
| title | A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| title_full | A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| title_fullStr | A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| title_full_unstemmed | A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| title_short | A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| title_sort | transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation |
| topic | Schizophrenia Bipolar disorder Social motivation Reward Approach/avoidance Social anhedonia |
| url | http://www.sciencedirect.com/science/article/pii/S2215001325000253 |
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