Metabolomics and network analysis reveal the mechanism of Salvia miltiorrhiza bunge extract in ameliorating cognitive dysfunction in sleep-deprived rats

Metabolomics and network analysis reveal the mechanism of Salvia miltiorrhiza bunge extract in ameliorating cognitive dysfunction in sleep-deprived rats

Abstract Sleep deprivation (SD) causes learning memory and cognitive impairment. Salvia miltiorrhiza Bunge (Danshen, DS), a medicinal plant in the family Labiatae, has been traditionally used for sleep-related disorders. Previous studies have shown that DS can ameliorate SD-induced cognitive impairm...

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Bibliographic Details
Main Authors: Meiya Zhang, Xirui Huang, Mengxiang Dai, Shunbo Zhang, Chao Yin, Qiuyun You
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Salvia miltiorrhiza bunge
Metabolomics
Network analysis
Sleep deprivation
Cognitive impairment
PIK3CA
Online Access:https://doi.org/10.1038/s41598-025-14303-6
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