MICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence o...
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| Format: | Article |
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| Language: | English |
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University of Tehran
2002-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31736_dc3cfca4d20bd301ad6ebb46e1a93456.pdf |
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| collection | DOAJ |
| description | Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, was also detected and purified. |
| format | Article |
| id | doaj-art-dbf0bc99db7b43dab9b1478c60e42d0b |
| institution | DOAJ |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2002-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-dbf0bc99db7b43dab9b1478c60e42d0b2025-08-20T03:08:48ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142002-06-0113231736MICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATISMycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, was also detected and purified.https://jsciences.ut.ac.ir/article_31736_dc3cfca4d20bd301ad6ebb46e1a93456.pdf |
| spellingShingle | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS Journal of Sciences, Islamic Republic of Iran |
| title | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS |
| title_full | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS |
| title_fullStr | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS |
| title_full_unstemmed | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS |
| title_short | MICROBIAL TRANSFORMATION OF CHOLESTEROL BY
MYCOBACTERIUM SMEGMATIS |
| title_sort | microbial transformation of cholesterol by mycobacterium smegmatis |
| url | https://jsciences.ut.ac.ir/article_31736_dc3cfca4d20bd301ad6ebb46e1a93456.pdf |