Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy
Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Ad...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/608397 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849472998933790720 |
|---|---|
| author | Jinhua Tang Haidong Yan Shougang Zhuang |
| author_facet | Jinhua Tang Haidong Yan Shougang Zhuang |
| author_sort | Jinhua Tang |
| collection | DOAJ |
| description | Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple biologically active molecules, including leptin, adiponectin, resistin, that affect inflammation, and subsequent deregulation of cell function in renal glomeruli that leads to pathological changes. Oxidative stress is also associated with obesity-related renal diseases and may trigger the initiation or progression of renal damage in obesity. In this paper, we focus on inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible interventions to prevent kidney injury in obesity. |
| format | Article |
| id | doaj-art-dbef0c6251fd45338500de3457a0a2e7 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-dbef0c6251fd45338500de3457a0a2e72025-08-20T03:24:20ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/608397608397Inflammation and Oxidative Stress in Obesity-Related GlomerulopathyJinhua Tang0Haidong Yan1Shougang Zhuang2Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaObesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple biologically active molecules, including leptin, adiponectin, resistin, that affect inflammation, and subsequent deregulation of cell function in renal glomeruli that leads to pathological changes. Oxidative stress is also associated with obesity-related renal diseases and may trigger the initiation or progression of renal damage in obesity. In this paper, we focus on inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible interventions to prevent kidney injury in obesity.http://dx.doi.org/10.1155/2012/608397 |
| spellingShingle | Jinhua Tang Haidong Yan Shougang Zhuang Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy International Journal of Nephrology |
| title | Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy |
| title_full | Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy |
| title_fullStr | Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy |
| title_full_unstemmed | Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy |
| title_short | Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy |
| title_sort | inflammation and oxidative stress in obesity related glomerulopathy |
| url | http://dx.doi.org/10.1155/2012/608397 |
| work_keys_str_mv | AT jinhuatang inflammationandoxidativestressinobesityrelatedglomerulopathy AT haidongyan inflammationandoxidativestressinobesityrelatedglomerulopathy AT shougangzhuang inflammationandoxidativestressinobesityrelatedglomerulopathy |