Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting
Abstract Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist thera...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | https://doi.org/10.1186/s12929-025-01167-1 |
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| author | Bo-Syong Pan Che-Chia Hsu Hsin-En Wu Yuan-Ru Chen Xiaobo Zhou Shu-Chi Wang Chia-Yang Li Hui-Kuan Lin |
| author_facet | Bo-Syong Pan Che-Chia Hsu Hsin-En Wu Yuan-Ru Chen Xiaobo Zhou Shu-Chi Wang Chia-Yang Li Hui-Kuan Lin |
| author_sort | Bo-Syong Pan |
| collection | DOAJ |
| description | Abstract Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist therapies. Beyond producing energy and building blocks to meet cancer cell demands, glucose metabolism generates numerous metabolites that serve as signaling molecules, orchestrating signaling pathways and epigenetic modifications that regulate cancer cell phenotypes and immunity. In this review, we discuss how glucose, through its metabolism and direct actions, influences diverse biological processes driving cancer progression and therapeutic resistance, while also exploring metabolic vulnerabilities in cancer for therapeutic strategies. |
| format | Article |
| id | doaj-art-dbeb3dfa0b914e6a8c896f204e50406f |
| institution | Kabale University |
| issn | 1423-0127 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj-art-dbeb3dfa0b914e6a8c896f204e50406f2025-08-20T03:43:20ZengBMCJournal of Biomedical Science1423-01272025-07-0132112110.1186/s12929-025-01167-1Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targetingBo-Syong Pan0Che-Chia Hsu1Hsin-En Wu2Yuan-Ru Chen3Xiaobo Zhou4Shu-Chi Wang5Chia-Yang Li6Hui-Kuan Lin7Department of Pathology, Duke University Medical Center, Duke University School of MedicineDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineCenter for Computational Systems Medicine, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at HoustonDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineDepartment of Pathology, Duke University Medical Center, Duke University School of MedicineAbstract Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist therapies. Beyond producing energy and building blocks to meet cancer cell demands, glucose metabolism generates numerous metabolites that serve as signaling molecules, orchestrating signaling pathways and epigenetic modifications that regulate cancer cell phenotypes and immunity. In this review, we discuss how glucose, through its metabolism and direct actions, influences diverse biological processes driving cancer progression and therapeutic resistance, while also exploring metabolic vulnerabilities in cancer for therapeutic strategies.https://doi.org/10.1186/s12929-025-01167-1Glucose metabolismWarburg effectTumor microenvironmentImmune regulationGlucose sensorImmunotherapy resistance |
| spellingShingle | Bo-Syong Pan Che-Chia Hsu Hsin-En Wu Yuan-Ru Chen Xiaobo Zhou Shu-Chi Wang Chia-Yang Li Hui-Kuan Lin Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting Journal of Biomedical Science Glucose metabolism Warburg effect Tumor microenvironment Immune regulation Glucose sensor Immunotherapy resistance |
| title | Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting |
| title_full | Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting |
| title_fullStr | Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting |
| title_full_unstemmed | Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting |
| title_short | Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting |
| title_sort | glucose metabolism and its direct action in cancer and immune regulation opportunities and challenges for metabolic targeting |
| topic | Glucose metabolism Warburg effect Tumor microenvironment Immune regulation Glucose sensor Immunotherapy resistance |
| url | https://doi.org/10.1186/s12929-025-01167-1 |
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